Table 2.

Incidence of CKD≥3 in patients with T1D during 5- to 12-year follow-up according to quartiles of distributions of baseline circulating TNF pathway marker concentrations

QuartilePatients (n)Incidence per 1000 Person-Years (No. of Events)
Free TNFαTotal TNFαTNFR1TNFR2
Q115710 (11)9 (9)5 (6)3 (4)
Q215711 (12)8 (9)9 (10)9 (10)
Q315714 (13)9 (10)10 (11)9 (10)
Q415724 (21)33 (29)45 (42)48 (44)
P for trenda0.048<0.0001<0.0001<0.0001
  • Q1–Q4, quartiles 1–4. Quartile boundaries for 25th, 50th, and 75th percentiles, respectively, are as follows (pg/ml for all values). Free TNFα: 3.3, 4.6, 6.1; total TNFα: 5.5, 8.8, 12.7; TNFR1: 1170, 1371, 1670; TNFR2: 1810, 2197, 2690.

  • a Bonferroni correction was applied.