Table 4.

Net reclassification improvement and integrated discrimination improvement of including biomarkers in the risk factor model to predict AKI progression

Category-Free NRI (SE), P ValueNRI in Progressors (SE)NRI in Nonprogressors (SE)IDI (SE), P Value
Serum creatinine0.172 (0.159), 0.280.022 (0.149), 0.880.150 (0.055), 0.0060.012 (0.008), 0.16
Urine ACR0.423 (0.161), 0.0080.500 (0.151), <0.0001−0.077 (0.055), 0.170.021 (0.011), 0.06
Urine NGAL0.541 (0.159), 0.00070.511 (0.149), 0.00060.030 (0.055), 0.580.042 (0.015), 0.004
Urine IL-180.442 (0.159), 0.005−0.200 (0.149), 0.180.642 (0.055), <0.00010.019 (0.011), 0.09
Plasma NGAL0.694 (0.161), <0.00010.455 (0.151), 0.0030.240 (0.057), <0.00010.06 (0.016), <0.001
  • Clinical model contains age, sex, white race, CPB time>120 minutes, nonelective surgery, preoperative eGFR, diabetes, hypertension, intraoperative IABP, repeat cardiac surgery during the hospitalization, and percent change in postoperative serum creatinine.