Table 1.

Light microscopy findings before and after eculizumab treatment

DDD1DDD3C3GN1C3GN2C3GN3
BeforeAfterBeforeAfterBeforeAfterBeforeAfterBeforeAfter
Predominant patternM/ECPMPMPMPMPGNMPGNMPGNMPGNMPMP
Glomeruli (n)9271011122726281410
Global sclerosis (%)2219302750850900
Segmental sclerosis (%)000188.33.70000
Mesangial proliferation (0–3)2221333211
Membranoproliferative features (0–3)1001331100
Leukocyte infiltration (0–3)2010112100
Endocapillary proliferation (0–3)2000002100
Crescents (%)0000000000
TBM deposits (0–3)2222000001
Tubulointerstitial scarring (%)151555406553005
  • M, mesangial; M/ECP, mesangial and endocapillary proliferative GN; MP, mesangial proliferative GN; MPGN, membranoproliferative GN.