Table 3.

Serum levels of IgA, normalized and total autoantigen (Gd-IgA1), IgG, normalized and total IgG autoantibody, and normalized and total IgA autoantibody in subgroups of IgAN patients according to the ARR of dialysis/death

ComparisonsIgAN
ARR = 0IgAN
ARR = 1IgAN
ARR = 2IgAN
ARR = 3
IgA (mg/ml)Mean (SD)2.17 (0.99)2.87 (1.10)3.28 (1.52)3.21 (1.58)
Median (range)2.25 (0.49–4.23)2.85 (1.24–5.13)3.15 (1.36–7.62)2.95 (1.43–8.01)
t testVersus ARR = 00.020.0030.01
Versus all controlsNS0.001<0.0001<0.0001
Gd-IgA1 (% HAA)Mean (SD)33.7 (13.5)32.6 (11.6)32.1 (14.6)34.2 (9.9)
Median (range)31.8 (17.1–73.1)32.0 (10.0–50.9)27.7 (13.4–76.5)32.0 (15.5–65.3)
t testVersus ARR = 0NSNSNS
Versus all controlsNSNSNSNS
Gd-IgA1 (U/ml)Mean (SD)71.4 (37.5)90.8 (40.9)100.2 (54.6)107.8 (56.2)
Median (range)68.1 (10.0–155.3)93.7 (26.8–167.2)84.3 (24.3–211.0)87.0 (39.0–267.5)
t testVersus ARR = 0NS (0.10)0.030.01
Versus all controlsNS0.020.0030.0003
IgG (mg/ml)Mean (SD)11.40 (2.69)10.94 (4.84)10.55 (3.79)8.47 (3.16)
Median (range)11.32 (5.62–16.08)9.75 (4.72–25.74)9.23 (6.71–21.72)8.65 (1.33–14.50)
t testVersus ARR = 0NSNS<0.001
Versus all controlsNSNSNS0.01
IgG autoantibody (OD/0.5 µg)Mean (SD)1.08 (0.36)1.23 (0.51)1.55 (0.71)2.05 (0.48)
Median (range)0.91 (0.63–1.73)0.95 (0.69–2.36)1.55 (0.68–3.01)2.13 (1.37–2.97)
t testVersus ARR = 0NS0.01<0.0001
Versus all controls0.04NS0.01<0.0001
IgG autoantibody (U/ml)Mean (SD)25.06 (11.45)28.38 (20.90)34.25 (23.33)35.18 (17.88)
Median (range)20.87 (9.73–48.26)23.28 (8.15–87.52)29.14 (10.15–91.72)30.84 (5.72–76.88)
t testVersus ARR = 0NSNS (0.08)0.02
Versus all controlsNSNS0.010.001
IgA autoantibody (OD/1 µg)Mean (SD)0.68 (0.50)0.69 (0.44)0.79 (0.47)0.83 (0.40)
Median (range)0.56 (0.23–2.19)0.56 (0.28–2,26)0.63 (0.21–2.31)0.69 (0.27–1.63)
t testVersus ARR = 0NSNSNS
Versus all controlsNSNSNSNS
IgA autoantibody (U/ml)Mean (SD1.59 (1.37)2.19 (1.88)2.66 (2.02)2.88 (2.49)
Median (range) (OD/1µg)1.21 (0.12–1.37)1.77 (0.46–8.60)1.96 (0.29–9.50)2.14 (0.71–10.63)
t testVersus ARR = 0NS0.030.03
Versus all controlsNS0.030.0010.0004
  • NS, not statistically significant.