Table 3.

Renal gene expression in Ksp-KL−/− mice on a regular and high phosphate diet

Gene TranscriptRegular DietHigh Phosphate Diet
WTKsp-KL−/−P ValueWTKsp-KL−/−P Value
Klotho1±0.060.51±0.06<0.00011±0.080.56±0.06<0.001
Cyp27B11±0.134.03±0.78<0.011±0.293.77±0.86<0.01
Cyp24A11±0.265.20±2.240.101±0.200.93±0.430.87
VDR1±0.100.86±0.050.231±0.100.57±0.07<0.01
Npt2a1±0.080.81±0.090.141±0.060.48±0.06<0.0001
Npt2c1±0.160.95±0.220.851±0.200.95±140.87
FGFR11±0.050.84±0.110.211±0.060.84±0.040.07
CaSR1±0.110.95±0.140.781±0.070.73±0.06<0.05
TRPV51±0.101.10±0.110.511±0.071.00±0.090.97
  • Data are mean ± SD. Transcript level of Cyp27B1 was significantly higher in Ksp-KL−/− mice on a regular diet. Cyp27B1, VDR, Npt2a, and CaSR were significantly changed in Ksp-KL−/− mice on a high phosphate diet in Ksp-KL−/− mice.