Table 1.

Serum biochemistry and gene expression in wild-type and Ksp-KL−/− mice with matched serum phosphate levels

ParametersWT (n=5)Ksp-KL−/− (n=5)P Value
Serum biochemistries
 FGF23 (pg/mL)79.6 (43.3–110–7)133.5 (74.3–193.3)<0.05
 Phosphate (mmol/L)2.73 (1.81–3.02)2.65 (1.80–2.91)0.90
 Calcium (mmol/L)1.76 (1.70–1.89)1.80 (1.67–1.92)0.80
 PTH (pg/mL)78.4 (65.8–93.0)79.4 (67.8–185.1)0.26
 1,25(OH)2D (pmol/L)132.2 (102.0–204.9)215.3 (115.3–382.4)0.34
 Creatinine (μmol/L)36.0 (28.5–40.5)39.0 (36.0–44.5)0.20
Gene expression
 Klotho1.12 (0.86–1.17)0.83 (0.51–1.13)0.13
 Cyp27B11.00 (0.44–1.38)2.45 (1.64–2.76)<0.001
 Cyp24A10.73 (0.27–2.36)2.32 (1.02–3.60)0.08
 VDR0.97 (0.69–1.39)1.21 (0.85–1.57)0.45
 Npt2a1.01 (0.67–1.35)0.98 (0.79–1.11)0.63
 Npt2c1.01 (0.53–1.79)0.82 (0.78–1.45)0.86
 FGFR11.06 (0.91–1.16)1.02 (0.74–1.34)0.73
 CaSR0.97 (0.62–1.33)0.87 (0.53–1.40)0.86
 TRPV50.98 (0.79–1.54)0.94 (0.75–1.21)0.72
  • FGF23 was the only serum variable differing between wild-type and Ksp-KL−/− mice in a subgroup analysis of mice with matched serum phosphate levels. In gene expression analysis, there was a marked increase of Cyp27B1 in the Ksp-KL−/− mice. Values are median (interquartile range).