Table 2.

Serum biochemistry as a function of residual Klotho expression

Serum BiochemistriesWT (KL=1)Ksp-KL−/− (KL >0.7)Ksp-KL−/− (KL 0.7–0.3)Ksp-KL−/− (KL <0.3)
FGF23 (pg/mL)83.3 (43.3–122.8)115.3 (74.3–193.3)160.4 (78.9–182.0)12,076 (3234–20,917)
Phosphate (mmol/L)2.71 (1.16–3.02)2.63 (1.80–3.20)3.09 (2.61–3.46)3.69 (3.07–4.32)
Calcium (mmol/L)1.74 (1.67–1.89)1.80 (1.67–1.92)1.86 (1.65–1.93)1.97 (1.84–2.10)
PTH (pg/mL)87.2 (65.8–188.9)76.5 (54.2–185.1)63.0 (53.2–79.4)55.2 (53.2–57.1)
1,25(OH)2D (pmol/L)176.8 (102.0–168.9)134.8 (81.1–215.3)161.0 (66.5–382.4)130.9 (n=1)
Creatinine (μmol/L)39.5 (28.5–41.0)37.5 (33.5–44.5)37.3 (32.5–41.0)36.5 (34.5–38.5)
  • In wild-type and Ksp-KL−/− mice, categorized into groups based on residual Klotho level, there was a gradual increase in serum FGF23, phosphate, and calcium levels and a reciprocal reduction in PTH level as Klotho expression declined.