Table 1.

Metabolic data at 8 weeks after the induction of diabetes

Control (n=8)DM (n=8)DM+T0901317 (n=8)
Systolic BP (mmHg)102.7±6.7115.9±3.8113.2±2.7
HbA1c (%)4.25±0.059.03±0.46a9.14±0.46a
Body weight (g)26.57±0.3518.66±1.23a20.23±0.79a
Kidney weight (mg)273.7±7.3311.3±20.0278.6±10.1
Relative kidney weight (mg/g body weight)11.23±0.4617.22±1.54a13.86±0.52b
Triglycerides (mg/dl)25.3±2.143.0±14.742.9±8.1
UAE (μg/24 h)9.3±1.282.8±11.7a52.9±7.5a,b
  • Data are means ± SEM. Control, nondiabetic control mice; DM, untreated diabetic mice; DM+T0901317, T0901317-treated diabetic mice; HbA1c, hemoglobin A1c; UAE, urinary albumin excretion.

  • a P<0.01 versus the control group.

  • b P<0.01 versus the DM group.