Table 2.

Renal substudy data from clearance studies performed at baseline and week 6 of each study period

VariablePlaceboSitaxentanNifedipine
BaselineWeek 6BaselineWeek 6BaselineWeek 6
GFR (ml/min)56±754±857±848±8a59±858±9
Effective renal blood flow (ml/min)533±66552±65511±63543±73562±82530±72
Effective renal vascular resistance (mmHg/min per L)230±52206±39236±44232±48248±58254±56
Effective filtration fraction (%)19.1±1.117.9±1.320.8±1.016.6±0.7b20.3±1.120.5±1.4
  • Values are given as predosing baseline ± SEM.

  • a P<0.05 for sitaxentan at week 6 versus sitaxentan at baseline.

  • b P<0.01 for sitaxentan at week 6 versus sitaxentan at baseline.