Table 1.

Renal function and glomerular histology at 38 weeks

GenotypeMice Assessed (n)Renal FunctionGlomerular Histology
Albuminuria (µg/24 h)Plasma Urea (mmol/L)Cellularity (0–3)Capillary Wall Thickening (0–2)Capillary Wall Double Contours (0–2)
P−/−110 (0–122)12.3 (9.9–16.3)1 (0–1)0 (0–1)0 (0–1)
CFH−/−.P−/−15125 (29–10,601)12.6 (9.9–21.4)2 (2–3)a,b2 (1–2)a,b1 (0–2)a,b
CFH−/−834 (0–69)10.9 (9.5–16)2 (1–2)a1 (0–2)a0 (0–1)
  • Values are presented as median (range).

  • a P<0.001 versus P−/− mice, Bonferroni multiple comparison test.

  • b P<0.05 versus CFH−/− mice, Bonferroni multiple comparison test.