Table 1.

Main study data at baseline and week 6 of each study period

VariablePlaceboSitaxentanNifedipine
BaselineWeek 6BaselineWeek 6BaselineWeek 6
24-hr proteinuria (g/d)2.06±0.382.00±0.332.07±0.341.46±0.26a1.95±0.301.99±0.33
Protein-to-creatinine ratio (mg/mmol)155±31153±27157±28114±23b155±27152±29
Mean arterial pressure (mmHg)94.6±2.294.3±1.794.4±1.890.7±1.8c95.5±2.091.7±1.7c
Systolic BP (mmHg)125.4±2.7124.2±1.9124.3±2.2120.7±1.9c125.7±2.4120.7±1.6c
Diastolic BP (mmHg)77.9±1.577.5±1.277.9±1.374.3±1.3a78. 9±1.575.7±1.2a
PWV (m/s)7.7±0.38.0±0.48.0±0.37.6±0.3c7.9±0.37.6±0.3c
Central augmentation index (%)20±220±220±215±2a19±217±2
Plasma ET-1 (pg/ml)3.6±0.53.7±0.63.6±0.53.7±0.53.5±0.53.5±0.5
Urine ET-1 (pg/ml)4.5±0.44.7±0.45.1±0.44.2±2.1c5.1±0.44.7±0.4
  • Values are given as predosing baseline ± SEM.

  • a P<0.01 for week 6 versus baseline.

  • b P=0.01 for week 6 versus baseline.

  • c P<0.05 for week 6 versus baseline.