Table 2.

Dialysis parameters outcome

Length of Follow-UpP
Baseline6 mo12 mo18 mo24 mo30 mo36 mo
Dialysis time (min)
 Hemodialysis234.1 (232.2, 236.1)235.5 (234.1, 236.9)235.6 (234.1, 237.1)235.7 (234.1, 237.4)236.5 (234.7, 238.3)238.3 (236.3, 240.2)237.5 (235.3, 239.6)0.07a
 OL-HDF235.8 (234.2, 237.3)234.4 (233.0, 235.9)234.2 (232.6, 235.7)234.8 (233.3, 236.4)235.7 (233.9, 237.5)235.9 (234.0, 237.8)236.6 (234.6, 238.7)0.14b
 Time × time0.300.180.430.550.090.580.80c
Qb (ml/min)
 Hemodialysis380 (374, 387)367 (363, 371)371 (366, 375)375 (370, 380)370 (365, 376)378 (372, 384)380 (374, 387)<0.001a
 OL-HDF392 (387, 398)384 (380, 388)386 (381, 391)384 (379, 389)385 (379, 390)385 (379, 391)389 (383, 395)<0.001b
  Time × time<0.001<0.0010.010.0010.090.040.54c
Qd (ml/min)
 Hemodialysis531 (520, 542)560 (553, 568)554 (546, 561)550 (542, 558)545 (536, 554)548 (538, 557)537 (526, 547)<0.001a
 OL-HDF553 (541, 564)571 (564, 579)571 (563, 578)575 (566, 583)575 (566, 583)580 (570, 590)566 (556, 577)<0.001b
 Time × time0.040.0020.0010.0010.0010.0010.14c
Replacement volume (L/session)
 Hemodialysis<0.001a
 OL-HDF21.8 (21.6, 22.0)21.5 (21.3, 21.8)21.1 (20.8, 21.4)20.8 (20.5, 21.1)21.2 (20.9, 21.5)21.7 (21.3, 22.0)0.01b
  Time × time0.0010.0010.0010.0010.0010.0010.01c
Intradialysis weight change (pre–post)
 Hemodialysis2.1 (2.0, 2.2)2.1 (2.0, 2.2)2.1 (2.0, 2.3)2.1 (1.9, 2.2)2.3 (2.1, 2.4)2.0 (1.8, 2.1)2.1 (1.9, 2.3)0.91a
 OL-HDF2.1 (2.0, 2.2)2.1 (1.9, 2.2)2.3 (2.1, 2.4)2.1 (2.0, 2.3)2.1 (1.9, 2.2)2.1 (2.0, 2.3)2.1 (1.9, 2.2)0.12b
  Time × time0.770.130.560.080.170.760.56c
Convection volume (L/session)
 Hemodialysis2.1 (2.0, 2.2)2.1 (1.8, 2.4)2.2 (1.9, 2.4)2.1 (1.7, 2.4)2.3 (1.9, 2.6)2.0 (1.6, 2.4)2.1 (1.7, 2.5)<0.001a
 OL-HDF2.1 (2.0, 2.2)23.9 (23.6, 24.2)23.8 (23.5, 24.1)23.2 22.9, 23.5)22.9 (22.5, 23.2)23.3 (22.9, 23.7)23.7 (23.3, 24.1)0.003b
 Time × time0.0010.0010.0010.0010.0010.0010.01c
  • Data are shown for every 6 months but were collected every 3 months. Data are presented as mean (95% CI) at baseline, and least-squares mean (95% CI) at 6 months, 12 months, 18 months, 24 months, 30 months, and 36 months. Analysis was conducted using a mixed model for repeated measures. Time × time indicates time × time comparisons, which are given as P values.

  • a P value of treatment effect.

  • b P value of time effect.

  • c P value of treatment × time interaction.