Table 4.

Adjusted associations of categories based on FGF23 and fractional excretion of phosphorus above versus below the median with mortality and CVD events stratified by CKD status

FGF23/FePi CategoryNo CKDCKD
ParticipantsEventsHR (95% CI)ParticipantsEventsHR (95% CI)
All-cause mortality
 Low FGF23/low FePi213531.00 (reference)27151.00 (reference)
 Low FGF23/high FePi146360.95 (0.61, 1.47)51261.05 (0.53, 2.07)
 High FGF23/high FePi109321.11 (0.70, 1.76)130871.88 (1.03, 3.43)
 High FGF23/low FePi137491.84 (1.22, 2.78)59392.10 (1.08, 4.09)
CVD events (MI, stroke, and CVD death)
 Low FGF23/low FePi213331.00 (reference)2761.00 (reference)
 Low FGF23/high FePi146230.90 (0.52, 1.55)51161.53 (0.58, 4.03)
 High FGF23/high FePi109180.96 (0.53, 1.72)130482.16 (0.89, 5.26)
 High FGF23/low FePi137321.81 (1.09, 2.99)59232.86 (1.10, 7.41)
  • Adjusted for age, sex, estrogen use (women), race, diabetes, systolic BP, BMI, total cholesterol, HDL cholesterol, smoking, CRP, eGFR, ACR, and PTH.