Table 3.

Associations of categories based on FGF23 and fractional excretion of phosphorus above versus below the median with mortality and CVD events

FGF23/FePi CategoryParticipantsEventsModel 1 HR (95% CI)Model 2 HR (95% CI)
All-cause mortalitya
 Low FGF23/low FePi240681.00 (reference)1.00 (reference)
 Low FGF23/high FePi197620.97 (0.68, 1.37)0.99 (0.70, 1.42)
 High FGF23/high FePi2391191.96 (1.45, 2.66)1.49 (1.07, 2.07)
 High FGF23/low FePi196882.21 (1.60, 3.06)1.98 (1.42, 2.77)
CVD events (MI, stroke, and CVD death)b
 Low FGF23/low FePi240391.00 (reference)1.00 (reference)
 Low FGF23/high FePi197391.09 (0.69, 1.70)1.04 (0.66, 1.63)
 High FGF23/high FePi239661.69 (1.13, 2.53)1.21 (0.78, 1.86)
 High FGF23/low FePi196552.22 (1.46, 3.36)1.92 (1.25, 2.94)
  • Model 1, age, sex, estrogen use (women), and race adjusted; model 2, model 1 plus diabetes, systolic BP, BMI, total cholesterol, HDL cholesterol, smoking, CRP, eGFR, ACR, and PTH.

  • a P interaction FGF23 × FePi<0.001.

  • b P interaction FGF23 × FePi=0.05.