Table 2.

Unadjusted incidence and rates of myocardial infarction by level of LDL-C for eGFR subgroups

LDL-C Category (mmol/L)eGFR=15–59.9 ml/min per 1.73 m2 (n=47,092)eGFR=60–89.9 ml/min per 1.73 m2 (n=351,849)eGFR≥90 ml/min per 1.73 m2 (n=437,119)
<2.6
 N (% within each column) with myocardial infarction579 (1.2%)1059 (0.3%)442 (0.1%)
 Unadjusted rate (95% CI) of myocardial infarction per 1000 patient-years9.7 (8.9, 10.5)3.4 (3.2,3.6)1.0 (0.9, 1.1)
2.6–3.39
 N (% within each column) with myocardial infarction535 (1.1%)1333 (0.4%)543 (0.1%)
 Unadjusted rate (95% CI) of myocardial infarction per 1000 patient-years7.8 (7.1, 8.4)2.7 (2.6, 2.9)1.0 (0.9, 1.1)
3.4–4.09
 N (% within each column) with myocardial infarction340 (0.7%)1042 (0.3%)466 (0.1%)
 Unadjusted rate (95% CI) of myocardial infarction per 1000 patient-years7.6 (6.8, 8.5)2.9 (2.7, 3.1)1.4 (1.3, 1.5)
4.1–4.89
 N (% within each column) with myocardial infarction182 (0.4%)532 (0.2%)306 (0.1%)
 Unadjusted rate (95% CI) of myocardial infarction per 1000 patient-years8.8 (7.6, 10.2)3.0 (2.8, 3.3)2.1 (1.9, 2.3)
≥4.9
 N (% within each column) with myocardial infarction64 (0.1%)225 (0.06%)114 (0.03%)
 Unadjusted rate (95% CI) of myocardial infarction per 1000 patient-years9.9 (7.7, 12.6)4.5 (4.0, 5.2)3.1 (2.6, 3.7)