Table 3.

Details of univariate and multivariate Cox analysis for PKD1 mutation carriers

VariablePatients (n)Univariate HR (95% CI)P ValueMultivariate HR (95% CI)P Value
Age
 <45 yr17011
 45–65 yr3062.75 (1.91–3.96)<0.00012.7 (1.88–3.93)<0.0001
 >65 yr8911.5 (5.42–24.5)<0.000111.48 (5.34–24.5)<0.0001
Gender
 Female22711
 Male2361.31 (1.01–1.68)0.0391.33 (1.03–1.72)0.029
Mutation type
 Nontruncating1421
 Truncating3212.6 (1.9–3.56)<0.00012.74 (2–3.76)0.0001
High BP
 Presence474
 Absence920.872 (0.53–1.43)0.40
Smoking (active or stopped)
 Yes209
 No3111.107 (0.84–1.44)0.47
Macroscopic hematuria
 Yes163
 No3581.195 (0.91–1.57)0.20
Mutation position 5′ versus 3′ end
 5′ end281
 3′ end2891.113 (0.86–1.43)0.41
Mutation position according to quartile of position
 1st quartile1471
 2nd quartile1381 (0.72–1.42)0.72
 3rd quartile1440.945 (0.67–1.34)0.75
 4th quartile1410.818 (0.57–1.17)0.67