Table 3.

HRs and RDs for high versus low and bolus versus maintenance dosing comparisons using expanded definitions of infection

Parameter Estimate (95% CI)Hospitalized for Infection of Any Organ SystemUse of IV AntibioticsHospitalized for Infection or Use of IV Antibiotics
High Versus LowBolus Versus MaintenanceHigh Versus LowBolus Versus MaintenanceHigh Versus LowBolus Versus Maintenance
Unadjusted HR1.32 (1.30 to 1.35)1.44 (1.41 to 1.47)1.24 (1.22 to 1.27)1.34 (1.32 to 1.37)1.27 (1.25 to 1.28)1.37 (1.35 to 1.39)
Adjusted HR1.03 (1.01 to 1.06)1.05 (1.03 to 1.08)1.02 (1.00 to 1.03)1.05 (1.03 to 1.07)1.02 (1.00 to 1.03)1.05 (1.03 to 1.07)
Adjusted RD/1000 person-yr13.9 (4.8 to 24.2)27.7 (17.5 to 38.0)12.3 (2.7 to 22.9)39.8 (27.4 to 53.0)18.3 (5.4 to 31.9)56.9 (38.3 to 72.5)
  • Adjusted analyses controlled for the following variables at baseline: age; race; sex; vintage; number of hospital days in the last month; history of infection in the last month; BMI; most recent vascular access; hemoglobin; ferritin; index TSAT; iron dose; albumin level; EPO dose; history in the last 6 months of pneumonia, sepsis, vascular access infection, diabetes, stroke, MI, chronic obstructive pulmonary disease, cancer, or GI bleeding; and EPO dose during exposure (n=776,203).