Table 2.

HRs and RDs for high versus low dose and bolus versus maintenance dosing comparisons

Parameter Estimate (95% CI)High Versus Low DoseBolus Versus Maintenance Dosing
Hospitalized for InfectionInfection-Related DeathInfection-Related Hospitalization or DeathHospitalized for InfectionInfection-Related DeathInfection-Related Hospitalization or Death
Unadjusted HR1.37 (1.33 to 1.40)1.43 (1.32 to 1.55)1.37 (1.34 to 1.40)1.51 (1.47 to 1.56)1.63 (1.48 to 1.78)1.52 (1.48 to 1.56)
Adjusted HR1.05 (1.02 to 1.07)1.08 (0.99 to 1.19)1.05 (1.02 to 1.08)1.08 (1.05 to 1.11)1.11 (1.00 to 1.23)1.08 (1.05 to 1.11)
Adjusted RD/1000 person-yr12.1 (5.7 to 18.8)1.2 (−0.74 to 2.8)13.0 (6.2 to 19.5)24.8 (15.8 to 33.1)2.0 (−0.36 to 4.1)26.1 (17.6 to 35.0)
  • Adjusted analyses controlled for the following variables at baseline: age; race; sex; vintage; number of hospital days in the last month; history of infection in the last month; BMI; most recent vascular access; hemoglobin; ferritin; index TSAT; iron dose; albumin level; EPO dose; history in the last 6 months of pneumonia, sepsis, vascular access infection, diabetes, stroke, MI, chronic obstructive pulmonary disease, cancer, or GI bleeding; and EPO dose during exposure (n=776,203).