Table 1.

Baseline characteristics of participants free of CKD at ARIC visit 1 (1987–1989) overall and by number of APOL1 risk alleles

CharacteristicOverall Sample (n=3067)Zero or One APOL1 Risk Allele (n=2663)Two APOL1 Risk Alleles (n=404)P Value Comparing Two with Zero or One Allele
Age (yr)53.2±5.853.3±5.852.7±5.60.04
Women, n (%)1927 (62.8)1669 (62.7)258 (63.9)0.65
Study center, n (%)0.41
 Forsyth County, NC328 (10.7)280 (10.5)48 (11.9)
 Jackson, MS2739 (89.3)2383 (89.5)356 (88.1)
Hypertension, n (%)1644 (53.6)1415 (53.1)229 (56.7)0.18
Systolic BP (mmHg)127±20127±20128±200.43
Diastolic BP (mmHg)80±1279±1280±120.08
Hypertension medication use, n (%)1189 (38.8)1025 (38.5)164 (40.6)0.30
Fasting blood glucose (mg/dl)a111±42111±42110±380.52
Diabetes, n (%)536 (17.5)458 (17.2)78 (19.3)
Body mass index (kg/m2)b29.6±6.129.5±6.130.0±6.10.20
Total cholesterol (mg/dl)215±45215±44212±490.29
HDL cholesterol (mg/l)c55±1855±1856±190.43
eGFR (ml/min per 1.73 m2)104.6±16.7104.7±16.6104.5±17.20.89
Global ancestry (% European ancestry)d18±1018±1015±8<0.001
APOL1 risk allele frequencies
 G10.22
 G20.13
APOL1 genotype frequencies, n (%)
 WT/WT1270 (41.4)
 WT/G1859 (28.0)
 WT/G2534 (17.4)
 G1/G2201 (6.6)
 G1/G1153 (5.0)
 G2/G250 (1.6)
  • Aa±.5±e F Glomerular Filtration

  • a Fasting blood glucose was available in 2877 participants overall (2504 participants carrying zero or one risk allele and 373 participants carrying two risk alleles).

  • b Body mass index was available in 3064 participants (2661 participants with zero or one allele and 403 participants with two alleles).

  • c HDL and total cholesterol were available in 3006 participants (2611 participants with zero or one allele and 395 participants with two alleles).

  • d Global ancestry was available in 2740 participants (2373 participants with zero or one allele and 367 participants with two alleles).