Table 3.

HRs (95% CIs) for incident CKD and incident ESRD associated with two copies of APOL1 risk alleles (compared with zero or one risk allele) stratified by baseline diabetes and hypertension status

ModelHR (95% CI)P ValueHR (95% CI)P Value
Incident CKD
 Stratified by diabetes (P for interaction=0.82)No diabetes (n=2531)Diabetes (n=536)
  Model 1a1.54 (0.95 to 2.49)0.081.41 (0.76 to 2.60)0.27
  Model 2b1.57 (0.95 to 2.61)0.081.43 (0.72 to 2.81)0.30
  Stratified by hypertension (P for interaction=0.08)No hypertension (n=1423)Hypertension (n=1644)
  Model 1a2.43 (1.24 to 4.78)0.011.13 (0.71 to 1.79)0.60
  Model 2b2.53 (1.25 to 5.14)0.011.12 (0.69 to 1.83)0.64
Incident ESRD
 Stratified by diabetes (P for interaction=0.66)No diabetes (n=2529)Diabetes (n=536)
  Model 1a2.00 (0.99 to 4.04)0.061.64 (0.92 to 2.92)0.09
  Model 2b2.04 (0.96 to 4.35)0.061.71 (0.91 to 3.21)0.09
 Stratified by hypertension (P for interaction=0.14)No hypertension (n=1423)Hypertension (n=1642)
  Model 1a3.09 (1.42 to 6.73)0.0041.45 (0.84 to 2.50)0.19
  Model 2b2.87 (1.20 to 6.87)0.021.53 (0.86 to 2.72)0.15
  • a Model 1 adjusted for age, sex, and study center.

  • b Model 2 adjusted for age, sex, study center, and percent European ancestry.