Table 1.

Baseline characteristics of the study sample

CharacteristicOverall
N2948
Mean age, yr59 (10)
Women53 (1561)
Mean BMI, kg/m228.0 (5.2)
Mean systolic BP, mmHg128 (19)
Hypertension40.7 (1199)
Diabetes9.4 (278)
HDL cholesterol, mg/dl51 (16)
Triglycerides, mg/dla117 (82, 171)
CKD8.9 (261)
Mean eGFR, ml/min per 1.73 m287 (25)
Albuminuria17.5 (517)
Median biomarker levels indexed to urinary creatinine (25th, 75th percentiles)
 α1-microglobulin, ng/ml5.0 (2.0, 20.0)
  β2-microglobulin, ng/ml0.3 (0.05, 0.8)
 Calbindin, ng/ml0.4 (0.08, 1.0)
 Clusterin (Apolipoprotein J), ng/ml0.1 (0.01, 0.5)
 CTGF, pg/ml5.0 (2.0,10.0)
 Cystatin-C, ng/ml0.08 (0.01, 0.2)
 GST-α, pg/ml2.0 (1.0, 6.0)
 Kim-1, pg/mL4.0 (2.0, 7.0)
 NGAL, ng/ml0.1 (0.04, 0.4)
 Osteopontin, ng/ml9.2 (5.2, 13.5)
 TFF-3, ng/ml4.0 (2.0, 7.0)
 Tamm–Horsfall Protein (uromodulin), μg/ml0.09 (0.04, 0.2)
 Tissue inhibitor of matrix metalloproteinase-1, pg/ml9.0 (3.0, 20.0)
 Vascular endothelial growth factor, pg/ml2.2 (1.01, 3.5)
  • Data are shown as mean (SD) for continuous variables and percent (n) for categorical variables. Albuminuria was defined as a spot UACR of ≥17 mg/g in men and ≥25 mg/g in women.

  • a Median (25th, 75th percentiles).