Table 1.

Metabolic data for CDA1 WT and KO mice with and without diabetes for 20 weeks

GenotypeCDA1 WTCDA1 KO
Nondiabetic (n=15)Diabetic (n=12)Nondiabetic (n=13)Diabetic (n=9)
Plasma glucose (mmol/L)13.5±0.928.6±1.1a11.2±0.627.4±1.7a
Glycated Hb (%)4.3±0.111.7±0.5a4.8±0.312.3±0.8a
Body weight (g)33.3±0.925.7±0.5a31.2±0.5b26.8±0.6a
Kidney/body weight (%)0.55±0.020.83±0.04a0.55±0.020.77±0.04a
Urine volume (ml/d)0.8±0.119.7±1.8a0.7±0.219.0±3.6a
Albuminuria (μg/d)119±20302±37a153±24312±38c
Creatinine clearance (ml/min per m2)14.8±1.642.7±2.0a14.3±1.733.3±4.0c
  • Data are shown as mean ± SEM.

  • a P<0.001 versus nondiabetic.

  • b P<0.05 versus nondiabetic CDA1 WT.

  • c P<0.05 versus nondiabetic.