Table 4.

Predictors of log dialysate IL-6

VariableIncidentPrevalent
Coefficient (95% CI)P ValueCoefficient (95% CI)P Value
Age (per decade)0.04a (0.01 to 0.06)0.0020.05a (0.01 to 0.08)0.01
BMI0.0009 (−0.007 to 0.009)0.80.008 (−0.003 to 0.02)0.2
APD use−0.06 (−0.21 to 0.10)0.50.2 (−0.004 to 0.3)0.06
Systolic BP (per 10 mmHg)− 0.02b (− 0.03 to − 0.002)0.03-0.03a (−0.05 to −0.002)0.03
Male sex0.04 (−0.04 to 0.11)0.30.1 (−0.0003 to 0.2)0.051
Duration of PD (per yr)0.1 (−0.6 to 0.8)0.70.02 (−0.02 to 0.05)0.4
Biocompatible solution use0.0007 (−0.09 to 0.09)0.990.1 (−0.04 to 0.3)0.1
Icodextrin use0.3a (0.2 to 0.4)<0.0010.2a (0.07 to 0.3)0.003
Average glucose concentration (per g/L)0.01a (0.004 to 0.02)0.006−0.004 (−0.02 to 0.01)0.5
Dialysate TNF-α0.8a (0.6 to 1.0)<0.0010.7a (0.3 to 1.0)0.001
Dialysate IFN-γ0.006 (−0.1 to 0.1)0.90.02 (−0.1 to 0.2)0.8
Plasma IL-60.3a (0.2 to 0.4)<0.0010.3a (0.1 to 0.5)0.001
Plasma TNF-α−0.2 (−0.4 to 0.06)0.10.2 (−0.1 to 0.5)0.2
Plasma IFN-γ0.06 (−0.06 to 0.19)0.3−0.1 (−0.3 to 0.03)0.1
Plasma IL-1β−0.1 (−0.3 to 0.3)0.9−0.05 (−0.5 to 0.4)0.8
Diabetic0.01 (− 0.08 to 0.10)0.80.05 (−0.08 to 0.2)0.4
Comorbidity0.02 (−0.03 to 0.06)0.5−0.004 (−0.06 to 0.05)0.9
Urine volume (per L)0.03 (−0.02 to 0.08)0.2-0.1b (−0.2 to −0.02)0.01
Korean−0.02 (−0.2 to 0.2)0.8−0.2 (−0.5 to 0.1)0.3
  • A total of 497 and 327 patients were in the final models for incident and prevalent groups, respectively. Log10 transformations of dialysate IL-6 were used as the dependent variable. Cytokine coefficients are per log10 changes in concentration. Using diabetes status rather than comorbidity was not a significant predictor for either group. CI, confidence interval.

  • a P<0.01.

  • b P=0.01–0.05.