Table 5.

Predictors of log plasma IL-6

VariableIncidentPrevalent
CoefficientP ValueCoefficientP Value
Age (per decade)0.02a (0.007 to 0.04)0.0040.01 (−0.009 to 0.03)0.3
Body mass index0.0001 (−0.005 to 0.005)0.960.004 (−0.002 to 0.01)0.2
APD use0.04 (−0.06 to 0.14)0.40.003 (−0.08 to 0.09)0.9
Systolic BP (per 10 mmHg)0.003 (−0.007 to 0.014)0.5−0.009 (−0.02 to 0.004)0.2
Male sex 0.05 (−0.001 to 0.09)0.060.02 (−0.03 to 0.07)0.5
Duration of PD (per yr)−0.2 (−0.6 to 0.2)0.40.02b (0.0008 to 0.03)0.04
Biocompatible solution use0.003 (−0.05 to 0.06)0.9−0.02 (−0.10 to 0.06)0.6
Icodextrin use0.04 (−0.02 to 0.11)0.3−0.02 (−0.09 to 0.05)0.6
Average glucose concentration (per g/L)0.003 (−0.004 to 0.009)0.4−0.002 (−0.01 to 0.005)0.5
Dialysate IL-60.13a (0.07 to 0.18)<0.0010.09b (0.03 to 0.15)0.002
Dialysate IFN-γ0.07 (−0.003 to 0.15)0.060.04 (−0.04 to 0.1)0.3
Dialysate TNF-α−0.2b (−0.3 to −0.005)0.04−0.1 (−0.4 to 0.06)0.2
Plasma TNF-α0.4a (0.2 to 0.5)<0.0010.4a (0.2 to 0.5)<0.001
Plasma IFN-γ0.05 (−0.03 to 0.13)0.20.2a (0.07 to 0.3)0.001
Plasma IL-1β0.2b (0.001 to 0.4)0.0490.3b (0.07 to 0.5)0.01
Diabetic−0.05 (−0.1 to 0.007)0.090.07b (0.002 to 0.15)0.045
Comorbidity0.05a (0.02 to 0.08)0.0010.02 (−0.01 to 0.05)0.2
Urine volume (per L)−0.02 (−0.05 to 0.01)0.3−0.009 (−0.05 to 0.03)0.7
Korean0.03 (−0.05 to 0.11)0.4−0.04 (−0.1 to 0.1)0.4
  • A total of 497 and 310 patients were in the final models for incident and prevalent groups, respectively. Log10 transformations of plasma IL-6 were used as the dependent variable. Cytokine coefficients are per log10 changes in concentration. Using diabetes status rather than comorbidity was not a significant predictor in the incident group, but for the prevalent group diabetes was highly significant and there was a trend toward a better model with diabetes rather than comorbidity (Δ−2 log likelihood = 2.19). CI, confidence interval.

  • a P<0.01.

  • b P=0.01–0.05.