Table 1.

Effect of AC6 KO on kidney parameters in PKD KO mice

ParameterPKD KOPKD/AC6 KO
Body weight (g)6.8±0.6 (n=27)11.0±0.9a (n=15)
Kidney weight (g)0.6±0.1 (n=27)0.3±0.1a (n=15)
Kidney/body weight (%)8±2 (n=27)3±1a (n=15)
Kidney area (mm3)791±76 (n=27)419±80a (n=15)
Cysts/kidney section161±35 (n=12)78±14a (n=12)
Cyst size (mm2)1.18±0.27 (n=12)0.46±0.10a (n=12)
Kidney polycystin-1 mRNA (ΔCT PKD1-GAPDH)8.24±0.10 (n=5)8.69±0.33 (n=5)
  • All animals were euthanized at 33±2 days of age. ΔCT, threshold cycle; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

  • a P<0.05 versus PKD KO alone.