Table 5.

Comparison of the rate of change (per year) of biomarkers between the stable and decline periods

BiomarkerUnadjusted ComparisonAdjusted for Early/Late Periods and Mean eGFR
Mean Slope of Stable PeriodsMean Slope of Decline PeriodsUnadjusted Mean Slope Difference (Stable–Decline)P ValueAdjusted Mean Slope Difference (Stable–Decline)P Value
Serum
 Albumin (g/dl)−0.010.034−0.04 (0.05)0.35−0.01 (0.05)0.74
 Alkaline phosphatase (U/L)1.381.000.38 (2.7)0.89−0.45 (2.9)0.87
 Calcium (mg/dl)0.0430.068−0.03 (0.06)0.69−0.06 (0.07)0.25
 Glucose (mg/dl)0.11−1.301.4 (4.23)0.741.6 (4.49)0.71
 Serum urea nitrogen (mg/dl)−0.729.34−10.1 (1.8)<0.001−9.44 (1.95)<0.001
 Serum creatinine (mg/dl)−0.0420.77−0.81 (0.18)<0.001−0.71 (0.19)<0.001
 Serum urea nitrogen-to-creatinine  ratio0.0440.44−0.39 (0.46)0.39−0.45 (0.49)0.37
 eGFR (ml/min per 1.73 m2)1.49−8.049.53 (1.74)<0.0019.21 (1.78)<0.001
 Serum uric acid (mg/dl)−0.320.63−0.95 (0.21)<0.001−1.12 (0.21)<0.001
 Serum phosphorus (mg/dl)−0.0120.24−0.25 (0.08)0.002−0.2 (0.09)0.004
 Serum sodium (mmol/L)−0.210.47−0.68 (0.35)0.050−0.74 (0.37)0.056
 Serum hematocrit (%)0.41−1.481.88 (0.42)<0.0011.87 (0.44)<0.001
 Serum bicarbonate (mmol/L)0.57−0.531.1 (0.36)0.0020.87 (0.37)0.007
Urine
 Urine urea nitrogen (g/d)0.11−0.200.31 (0.34)0.360.31 (0.34)0.32
 Urine protein (g/d)0.0870.22−0.13 (0.12)0.25−0.15 (0.12)0.24
 Urine creatinine (g/d)0.016−0.0470.06 (0.04)0.140.06 (0.04)0.18
 Urine protein/creatinine ratio (g/g)0.0490.12−0.07 (0.07)0.30−0.06 (0.07)0.34
 Urine sodium (g/d)0.230.0260.2 (0.21)0.330.2 (0.21)0.31
 Urine potassium (g/d)0.046−0.0130.06 (0.11)0.600.01 (0.12)0.95
 Urine sodium-to-potassium  ratio (g/g)0.120.0180.1 (0.11)0.350.16 (0.11)0.17
  • The unadjusted or adjusted mean slope differences are expressed as the estimator (SEM).