Table 4.

Comparison of the average biomarker levels between the stable and decline periods

BiomarkerUnadjusted ComparisonAdjusted for Early/Late Periods and Mean eGFR
Mean of Stable PeriodsMean of Decline PeriodsUnadjusted Mean Difference (Stable–Decline)P ValueAdjusted Mean Difference (Stable–Decline)P Value
Serum
 Albumin (g/dl)4.164.030.13 (0.03)<0.0010.12 (0.03)<0.001
 Alkaline phosphatase (U/L)93.297.4−4.27 (2.45)0.08−1.93 (2.31)0.38
 Calcium (mg/dl)9.349.44−0.1 (0.07)0.14−0.01 (0.05)0.87
 Glucose (mg/dl)100.9100.60.32 (2.06)0.881.74 (1.95)0.35
 Serum urea nitrogen (mg/dl)26.531.4−4.87 (2.26)0.03−0.89 (1.45)0.50
 Serum creatinine (mg/dl)2.052.43−0.38 (0.14)0.005−0.15 (0.09)0.12
 Serum urea nitrogen-to-creatinine  ratio13.0913.060.03 (0.52)0.950.5 (0.49)0.30
 eGFR (ml/min per 1.73 m2)47.543.24.36 (1.71)0.0100.67 (0.27)0.02
 Serum uric acid (mg/dl)8.558.540.01 (0.23)0.950.13 (0.24)0.62
 Serum phosphorus (mg/dl)3.423.71−0.29 (0.08)<0.001−0.18 (0.07)0.005
 Serum sodium (mmol/L)138.4139.0−0.63 (0.35)0.07−0.27 (0.33)0.45
 Serum hematocrit (%)39.338.31.05 (0.43)0.010.55 (0.38)0.13
 Serum bicarbonate (mmol/L)26.025.90.08 (0.35)0.82−0.16 (0.35)0.61
Urine
 Urine urea nitrogen (g/d)8.378.100.27 (0.28)0.330.07 (0.28)0.81
 Urine protein (g/d)0.361.01−0.65 (0.15)<0.001−0.49 (0.14)<0.001
 Urine creatinine (g/d)1.601.570.04 (0.05)0.470 (0.05)0.95
 Urine protein/creatinine  ratio (g/g)0.210.69−0.48 (0.12)<0.001−0.36 (0.11)<0.001
 Urine sodium (g/d)4.023.720.3 (0.19)0.110.27 (0.19)0.12
 Urine potassium (g/d)2.062.050.01 (0.09)0.94−0.07 (0.09)0.43
 Urine sodium-to-potassium  ratio (g/g)2.292.100.19 (0.11)0.070.26 (0.11)0.02
  • The unadjusted or adjusted mean differences are expressed as the estimator (SEM).