Table 1.

Demographic baseline characteristics of participants (all cases and controls were HIV-infected African Americans)

CharacteristiceGFR<60 CohortNephrotic Proteinuria Cohort
Cases (n=46)IQRControls (n=92)IQRP ValueCases (n=44)IQRControls (n=88)IQRP Value
Median age (yr)5044, 584233, 49<0.0014537, 524033,480.05
Men, n (%)23 (50)68 (74)<0.0134 (77)75 (85)0.24
Median eGFR (ml/min per 1.73 m2)54.249.3, 58.4105.894.9, 125.4<0.001a100.778.4, 114.9105.893.6, 118.60.08
Median UP/Cr (g/g)0.200.1, 0.770.100.06, 0.149<0.016.375.17, 13.000.050.04, 0.07<0.001a
Median CD4 count (cells/mm3)284165, 607361144, 6080.81419255, 554410244, 6730.61
Viral load<50 copies/ml, n (%)26 (58)54 (59)0.3033 (77)66 (75)0.69
Median log10 viral load1.771.69, 3.371.691.69, 4.140.051.691.69, 2.761.691.69, 2.270.46
Diabetes, n (%)b7 (15)10 (11)0.459 (21)1 (1)<0.001a
Median fasting blood glucose (mg/dl)9183, 978983, 980.469176, 1088779, 970.04a
Hypertension, n (%)b33 (72)33 (36)<0.00124 (55)27 (31)<0.01
HCV infection, n (%)b13 (28)14 (15)0.0910 (23)5 (6)<0.01
Median fasting cholesterol (mg/dl)189156, 224173150, 2020.07189173, 230180164, 2010.26
Median fasting HDL cholesterol (mg/dl)4337, 544838, 560.764635, 655041, 610.54
Median fasting LDL cholesterol (mg/dl)11091, 13510277, 1230.2010567, 14010890, 1250.78
Median fasting triglycerides (mg/dl)146101, 25610575, 1500.02161114, 22810074, 1380.02
  • IQR, interquartile range.

  • a Determined by Wilcoxon or Fisher exact tests because logistic regression models did not converge.

  • b Diagnosis before case/control assignment.