Table 4.

Association of predialysis systolic BPV with outcomes after stratification by baseline predialysis systolic BP categories in 11,291 incident hemodialysis patients

OutcomesBP Range (mmHg)EventsNCrudeaMinimally AdjustedbFully Adjustedc
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
All-cause mortality
 Q1.1<12548311681.28 (1.19 to 1.38)<0.0011.31 (1.22 to 1.42)<0.0011.22 (1.11 to 1.34)<0.001
 Q1.2125–13332810621.36 (1.23 to 1.51)<0.0011.42 (1.28 to 1.58)<0.0011.11 (0.99 to 1.26)0.08
 Q2133–14564324021.39 (1.30 to 1.48)<0.0011.44 (1.35 to 1.53)<0.0011.16 (1.08 to 1.24)<0.001
 Q3145–15555521751.42 (1.32 to 1.53)<0.0011.50 (1.38 to 1.63)<0.0011.22 (1.13 to 1.32)<0.001
 Q4155–16755121711.39 (1.28 to 1.51)<0.0011.44 (1.32 to 1.56)<0.0011.16 (1.08 to 1.26)<0.001
 Q5>16764022741.28 (1.21 to 1.37)<0.0011.34 (1.26 to 1.43)<0.0011.19 (1.11 to 1.27)<0.001
CV mortality
 Q1.1<12524111681.35 (1.20 to 1.51)<0.0011.37 (1.22 to 1.55)<0.0011.30 (1.14 to 1.48)<0.001
 Q1.2125–13316810621.38 (1.22 to 1.56)<0.0011.41 (1.25 to 1.60)<0.0011.16 (1.00 to 1.35)0.05
 Q2133–14531424021.30 (1.17 to 1.43)<0.0011.35 (1.21 to 1.49)<0.0011.13 (1.01 to 1.26)0.03
 Q3145–15525921751.39 (1.25 to 1.55)<0.0011.47 (1.31 to 1.65)<0.0011.20 (1.07 to 1.34)0.002
 Q4155–16727621711.29 (1.16 to 1.44)<0.0011.33 (1.19 to 1.49)<0.0011.12 (1.01 to 1.25)0.04
 Q5>16734022741.29 (1.19 to 1.41)<0.0011.34 (1.23 to 1.47)<0.0011.20 (1.09 to 1.31)<0.001
CV events
 Q1.1<12551311681.16 (1.06 to 1.26)<0.0011.17 (1.07 to 1.28)<0.0011.11 (1.01 to 1.23)0.04
 Q1.2125–13343510641.19 (1.10 to 1.30)<0.0011.21 (1.10 to 1.32)<0.0011.12 (1.02 to 1.22)0.01
 Q2133–14588124071.22 (1.14 to 1.30)<0.0011.22 (1.13 to 1.32)<0.0011.09 (1.01 to 1.17)0.03
 Q3145–15582321801.20 (1.12 to 1.29)<0.0011.23 (1.14 to 1.33)<0.0011.11 (1.03 to 1.20)0.01
 Q4155–16787621741.18 (1.11 to 1.27)<0.0011.20 (1.12 to 1.29)<0.0011.10 (1.03 to 1.18)0.01
 Q5>167100022791.15 (1.09 to 1.22)<0.0011.18 (1.11 to 1.25)<0.0011.11 (1.04 to 1.18)<0.001
  • HR per 1 SD increase in the predialysis systolic BPV metric. Q1.1 to Q5 refers to categories of systolic BP at baseline (quintiles [fifths] of systolic BP, with the lowest quintile [Q1] further subdivided into two categories at the median [Q1.1 and Q1.2]).

  • a Unadjusted model.

  • b Adjusted for age, sex, race, and ethnicity.

  • c Adjusted for demographic characteristics (age, sex, race, and ethnicity), clinical factors (history of diabetes, CVD, CHF, comorbidity index, and BMI), ESRD-related factors (cause of ESRD, Kt/V, and relative fluid removal), laboratory measurements (serum albumin, calcium–phosphate product, hemoglobin, and ferritin), and antihypertensive medications.