Table 5.

Associations of selected clinical characteristics with change in GFR estimated from serum concentrations of creatinine, cystatin C, or both among all 1441 participants over combined DCCT/EDIC follow-up

Risk FactorDifference in Change in eGFRCr (ml/min per 1.73 m2 per year)Difference in Change in eGFRCys (ml/min per 1.73 m2 per year)Difference in Change in eGFRCr+Cys (ml/min per 1.73 m2 per year)
Age at DCCT baseline (yr)
 <200 (Reference)0 (Reference)0 (Reference)
 20–29−0.15 (−0.26 to −0.05)−0.18 (−0.31 to −0.06)−0.13 (−0.25 to 0.01)
 ≥30−0.52 (−0.62 to −0.41)−0.64 (−0.77 to −0.51)−0.56 (−0.68 to −0.44)
 F values (df=2)62.763.358.6
P value<0.001<0.001<0.001
Sex
 Women0 (Reference)0 (Reference)0 (Reference)
 Men0.01 (−0.07 to 0.08)0.03 (−0.06 to 0.12)0.06 (−0.14 to 0.03)
 t value (df=1)0.210.621.30
P value0.830.540.19
Time-updated systolic BP (mmHg)
 <1200 (Reference)0 (Reference)0 (Reference)
 120–129−0.03 (−0.08 to 0.03)−0.07 (−0.14 to 0.01)−0.04 (−0.10 to 0.03)
 ≥130−0.12 (−0.18 to −0.05)−0.22 (−0.30 to −0.14)−0.17 (−0.24 to −0.09)
 F values (df=2)6.8414.410.1
P value0.001<0.001<0.001
Mean DCCT hemoglobin A1c (%)
 <70 (Reference)0 (Reference)0 (Reference)
 7–7.90.07 (−0.03 to 0.17)−0.06 (−0.18 to 0.06)−0.00 (−0.11 to 0.11)
 8–8.9−0.07 (−0.18 to 0.04)−0.23 (−0.36 to −0.09)−0.18 (−0.30 to −0.05)
 9–9.9−0.22 (−0.34 to −0.10)−0.44 (−0.59 to −0.29)−0.39 (−0.53 to −0.25)
 ≥10−0.43 (−0.56 to −0.30)−0.79 (−0.95 to 0.64)−0.71 (−0.86 to −0.56)
 F values (df=2)18.531.331.2
P value<0.001<0.001<0.001
Time-updated albumin excretion rate (mg/d)
 <300 (Reference)0 (Reference)0 (Reference)
 30–299−0.07 (−0.07 to −0.08)−0.12 (−0.13 to −0.12)−0.08 (−0.09 to −0.07)
 ≥300−0.44 (−0.37 to −0.48)−0.54 (−0.64 to −0.45)−0.44 (−0.52 to −0.37)
 F values (df=2)68.770.164.5
P value<0.001<0.001<0.001
  • Mean changes in eGFR (ml/min per 1.73 m2) with 95% CI were −1.37 (−1.41 to −1.33) for eGFRCr, −1.11 (−1.16 to −1.06) for eGFRCys, and −1.29 (−1.33 to −1.24) for eGFRCr+Cys. df, degrees of freedom.