Table 2.

Cox regression for all-cause and cardiovascular mortality in the LURIC study according to categories of HDL-C serum levels

ModeleGFR
(ml/min per 1.73 m2)HDL CategoryAll-Cause MortalityCardiovascular Mortality
Events (%)HR (95% CI)P ValueEvents (%)HR (95% CI)P Value
Crude≥90C122.2118.01
C216.80.71 (0.42 to 1.20)0.209.30.49 (0.27 to 0.91)0.03
C319.50.84 (0.52 to 1.37)0.4912.40.66 (0.38 to 1.17)0.15
C415.60.65 (0.38 to 1.11)0.117.90.41 (0.21 to 0.79)0.01
C513.00.54 (0.30 to 0.97)0.045.40.28 (0.13 to 0.62)0.002
60–89C140.0125.61
C235.50.80 (0.58 to 1.11)0.1822.20.78 (0.52 to 1.17)0.23
C330.20.66 (0.48 to 0.91)0.0119.00.65 (0.44 to 0.97)0.04
C430.70.68 (0.48 to 0.95)0.0217.00.59 (0.38 to 0.91)0.02
C523.20.50 (0.34 to 0.73)< 0.00115.90.54 (0.38 to 0.86)0.01
<60C158.5137.71
C269.21.29 (0.86 to 1.93)0.2151.01.46 (0.89 to 2.40)0.13
C354.00.87 (0.57 to 1.33)0.5234.70.86 (0.51 to 1.47)0.59
C450.70.82 (0.51 to 1.33)0.4342.01.03 (0.59 to 1.83)0.91
C556.90.94 (0.57 to 1.53)0.7929.30.75 (0.39 to 1.42)0.38
Adjusted 1a≥90C122.2118.01
C216.80.65 (0.38 to 1.09)0.109.30.45 (0.24 to 0.84)0.01
C319.50.70 (0.43 to 1.15)0.1612.40.57 (0.32 to 1.01)0.05
C415.60.51 (0.30 to 0.89)0.027.90.34 (0.18 to 0.67)0.002
C513.00.43 (0.24 to 0.79)0.015.40.25 (0.11 to 0.55)0.001
60–89C140.0125.61
C235.50.76 (0.55 to 1.05)0.1022.20.74 (0.50 to 1.11)0.15
C330.20.62 (0.45 to 0.86)0.00419.00.62 (0.41 to 0.92)0.02
C430.70.65 (0.46 to 0.92)0.0117.00.56 (0.36 to 0.87)0.01
C523.20.47 (0.32 to 0.69)<0.00115.90.50 (0.31 to 0.81)0.01
<60C158.5137.71
C269.21.27 (0.85 to 1.90)0.2551.01.46 (0.89 to 2.40)0.13
C354.00.91 (0.59 to 1.40)0.6734.70.86 (0.51 to 1.47)0.59
C450.70.85 (0.52 to 1.39)0.5342.01.03 (0.59 to 1.83)0.91
C556.90.96 (0.58 to 1.61)0.8829.30.75 (0.39 to 1.43)0.38
Adjusted 2b≥90C122.2118.01
C216.80.67 (0.39 to 1.14)0.139.30.45 (0.24 to 0.85)0.01
C319.50.75 (0.44 to 1.27)0.2312.40.60 (0.32 to 1.11)0.10
C415.60.57 (0.31 to 0.94)0.047.90.37 (0.17 to 0.78)0.01
C513.00.51 (0.26 to 0.92)0.035.40.30 (0.13 to 0.73)0.01
60–89C140.0125.61
C235.50.88 (0.63 to 1.22)0.4422.20.90 (0.59 to 1.36)0.61
C330.20.78 (0.56 to 1.09)0.1519.00.83 (0.54 to 1.27)0.39
C430.70.88 (0.61 to 1.27)0.5017.00.84 (0.52 to 1.34)0.46
C523.20.68 (0.45 to 1.04)0.0715.90.84 (0.50 to 1.40)0.50
<60C158.5137.71
C269.21.36 (0.90 to 2.05)0.1551.01.52 (0.92 to 2.53)0.11
C354.01.03 (0.66 to 1.61)0.9034.71.02 (0.59 to 1.78)0.94
C450.70.95 (0.56 to 1.59)0.8342.01.18 (0.64 to 2.19)0.60
C556.91.18 (0.60 to 1.81)0.8829.30.82 (0.40 to 1.69)0.60
  • The categories are as follows: C1, ≤25 mg/dl; C2, 26–33 mg/dl; C3, 34–41 mg/dl; C4, 42–49 mg/dl; and C5, ≥50 mg/dl. Category 1 is used as the reference.

  • a Adjusted for age and sex.

  • b Adjusted for age, sex, glycated hemoglobin, systolic BP, body mass index, acute coronary syndrome, Friesinger score, lipid-lowering therapy, smoking status, and hsCRP.