Table 2.

Regression coefficients for the association of urinary sulfate and thiosulfate with cardiovascular parameters in 707 RTRs

Dependent VariableModel 1Model 2Model 3Model 4
βP ValueβP ValueβP ValueβP Value
Sulfate
 SBP, mmHg−0.210.06−0.210.05−0.340.004−0.330.01
 DBP, mmHg0.040.520.050.51−0.010.90−0.010.98
 Mean arterial  pressure, mmHg−0.040.62−0.040.61−0.120.15−0.110.20
 Pulse pressure, mmHg−0.250.002−0.260.004−0.33<0.001−0.32<0.001
 Heart rate, bpm−0.130.09−0.160.04−0.150.08−0.140.11
 NT-proBNP, ng/La−0.05<0.001−0.04<0.001−0.03<0.001−0.030.001
 hs-CRP, mg/La−0.03<0.001−0.03<0.001−0.04<0.001−0.030.002
 HbA1c, %−0.010.13−0.020.03−0.020.007−0.010.02
 eGFR, ml/min  per 1.73 m20.59<0.0010.48<0.0010.310.01
 Proteinuria, g/24 ha−0.050.02−0.030.19−0.040.002−0.04<0.001
Thiosulfate
 SBP, mmHg−0.050.16−0.030.27−0.030.220.020.69
 DBP, mmHg0.010.920.010.850.010.870.010.82
 Mean arterial  pressure, mmHg−0.010.34−0.010.93−0.010.920.020.77
 Pulse pressure, mmHg−0.050.37−0.040.46−0.040.470.010.82
 Heart rate, bpm−0.060.69−0.100.12−0.090.14−0.070.26
 NT-proBNP, ng/La−0.03<0.001−0.03<0.001−0.03<0.001−0.020.01
 hs-CRP, mg/La−0.02<0.001−0.01<0.001−0.02<0.001−0.010.01
 HbA1c, %−0.010.48−0.010.18−0.010.19−0.010.55
 eGFR, ml/min  per 1.73 m20.43<0.0010.34<0.0010.28<0.001
 Proteinuria, g/24 ha−0.020.001−0.010.08−0.010.06−0.010.31
  • Coefficients are provided as standardized β values, referring to the number of SDs the dependent variable changes, per SD increase of sulfate or thiosulfate. Model 1, adjusted for age, sex and BSA; model 2, additionally adjusted for eGFR and time since transplantation; model 3, additionally adjusted for urinary sodium excretion (mmol/24 h), drugs (antihypertensives, calcineurin inhibitors, proliferation inhibitors); and model 4, additionally adjusted for either sulfate or thiosulfate.

  • a Log-transformed for analyses.