Table 3.

Urinary cell diagnostic signature score: subgroup analysis

VariablesSix-Gene Signature Score (AR versus ATI) Median ValueaFive-Gene Signature Score (ACR versus AMR) Median Valuea
NAR (n=52)ATI (n=32)P ValueNACR (n=26)AMR (n=26)P Value
Biopsy within 1 mo of transplantation311.15−1.47<0.0011910.187.87<0.001
Biopsy beyond 1 mo of transplantation530.77−1.41<0.0013310.218.10<0.001
 P value0.70.60.70.3
Men520.98−1.45<0.0013310.297.95<0.001
Women320.77−1.46<0.0011910.117.88<0.01
 P value0.70.70.70.6
Black281.08−1.36<0.0011910.348.05<0.001
Others560.77−1.46<0.0013310.087.90<0.001
 P value0.70.80.50.6
Black donor171.61−1.87<0.011210.298.38<0.01
Other donor670.77−1.45<0.0014010.187.87<0.001
 P value0.60.30.90.2
Living donor411.11−1.45<0.0012710.338.70<0.001
Deceased donor430.47−1.46<0.0012510.117.87<0.001
 P value0.10.70.50.04
History of delayed graft function261.30−1.34<0.0011310.177.95<0.01
No delayed graft function580.77−1.46<0.0013910.227.92<0.001
 P value0.90.60.90.7
Induction immunosuppression761.01−1.46<0.0014410.117.98<0.001
No induction immunosuppression80.77b811.067.40c
 P value0.90.2
Lymphocyte-depleting induction immunosuppression (Thymoglobulin)d591.11−1.50<0.0013210.188.31<0.001
Lymphocyte-nondepleting induction (IL-2 receptor antibody) or no induction250.62−1.11<0.012010.207.90<0.001
 P value0.50.10.70.7
Maintenance immunosuppression with corticosteroids400.77−1.45<0.0013310.617.87<0.001
Maintenance immunosuppression without corticosteroids441.30−1.46<0.0011910.098.65<0.001
 P value0.40.80.40.1
History of bacterial urinary tract infection220.77−1.27<0.011710.08.0<0.001
No bacterial urinary tract infection621.01−1.46<0.0013510.37.9<0.001
 P value0.80.50.40.6
ACR, Banff 4 IA/IB201.362010.09
ACR, Banff 4 IIA/IIB60.49611.14
 P value0.30.1
Concomitant interstitial fibrosis/tubular atrophy, nil to mild730.77−1.46<0.0014210.257.87<0.001
Concomitant interstitial fibrosis/tubular atrophy, moderate to severe111.36−0.55c109.668.650.02
 P value0.90.80.3
  • a Median values of the two diagnostic signature scores are shown for different subgroups of patient variables. P values are derived using the Mann–Whitney test.

  • b There were no patients in the ATI and no induction immunosuppression group.

  • c n≤2. Hence, no statistical comparisons were done.

  • d Includes one patient with alemtuzumab (Campath) induction.