Table 2.

Characteristics of study participants based on the occurrence of class I and II adverse safety events

Demographic VariableEventsaClass I and Class II EventsClass I but No Class II EventsClass II but No Class I EventsTotal
All participants, n (row %)82 (30.7)48 (18.0)106 (39.7)31 (11.6)267 (100.0)
Age
 Mean±SD (yr)65.7±12.665.7±12.665.7±12.665.7±12.665.7±12.6
 <65 yr, n (%)32 (39.0)23 (47.9)48 (45.3)15 (48.4)118 (44.2)
  ≥65 yr, n (%)50 (61.0)25 (52.1)58 (54.7)16 (51.6)149 (55.8)
Sex, n (%)
 Female21 (25.6)18 (37.5)26 (24.5)10 (32.3)75 (28.1)
 Male61 (74.4)30 (62.5)80 (75.5)21 (67.7)192 (71.9)
African American, n (%)
 No23 (28.1)17 (35.4)35 (33.0)10 (32.3)85 (31.8)
 Yes59 (72.0)31 (64.6)71 (67.0)21 (67.7)182 (68.2)
Diabetes, n (%)
 No49 (59.8)10 (20.8)28 (26.4)11 (35.5)98 (36.7)
 Yes33 (40.2)38 (79.2)78 (73.6)20 (64.5)169 (63.3)
Cancer, n (%)
 No69 (84.1)38 (79.2)81 (76.4)25 (80.7)213 (79.8)
 Yes13 (15.9)10 (20.8)25 (23.6)6 (19.3)54 (20.2)
Cardiovascular disease, n (%)
 No54 (65.9)17 (35.4)35 (33.0)10 (32.3)116 (43.4)
 Yes28 (34.1)31 (64.6)71 (67.0)21 (67.7)151 (56.6)
GFR
 Mean±SD (ml/min per 1.73 m2)44.4±12.036.6±13.842.1±15.643.1±13.641.9±14.2
  ≥45 ml/min per 1.73 m2, n (%)38 (46.3)14 (29.2)46 (43.4)14 (45.2)112 (42.0)
 <45 ml/min per 1.73 m2, n (%)44 (53.7)34 (70.8)60 (56.6)17 (54.8)155 (58.0)
Annual household income, n (%)
  ≤$50,000b58 (70.7)36 (75.0)75 (70.8)26 (83.9)195 (73.0)
 >$50,00024 (29.3)12 (25.0)31 (29.2)5 (16.1)72 (27.0)
Education, n (%)
 No high school diploma43 (52.44)32 (66.67)48 (45.28)14 (45.16)137 (51.31)
 High school or greater39 (47.56)16 (33.33)58 (54.72)17 (54.84)130 (48.69)
Currently married, n (%)
 No56 (68.29)25 (52.08)54 (50.94)21 (67.74)156 (58.43)
 Yes26 (31.71)23 (47.92)52 (49.06)10 (32.26)111 (41.57)
Hypertension, n (%)
 No3 (3.66)1 (2.08)6 (5.66)0 (0.00)10 (3.75)
 Yes79 (96.34)47 (97.92)100 (94.34)31 (100.00)257 (96.25)
Median medications (interquartile range) (n)c
10 (7–14)14 (12–17)14 (11–19)11 (9–15)13 (9–17)
  • All percentages are column percentages unless otherwise indicated.

  • a All detected events are conditional on use of a drug from a class listed in Table 1.

  • b Includes participants who declined to answer.

  • c Number of medication components.