Table 3.

Comparisons of eGFR and echocardiographic parameters at baseline and 1 year and changes over 1 year across the different CKD stages

VariableStage 3a (n=61)Stage 3b (n=77)Stages 4 and 5 (n=140)P Value
eGFR (ml/min per 1.73m2)
 Baseline53.3±5.836.6±4.117.9±6.5<0.001
 1 yr52.4±9.034.6±6.414.8±7.7<0.001
 Change−0.92 (−4.75, 3.35)−1.85 (−4.49, 1.66)−2.77 (−5.11, −0.86)0.01
LV mass index (g/m2)
 Baseline95.5±22.795.6±25.4114.8±36.5<0.001
 1 yr100.2±21.4100.5±25.5122.6±38.5<0.001
 Change4.19 (0.66, 12.17)3.67 (−0.35, 9.58)7.15 (0.96, 12.81)0.04
LV volume index (ml/m2)
 Baseline41.0±8.039.4±9.045.4±12.7<0.001
 1 yr40.7±7.740.2±8.747.3±13.6<0.001
 Change0.06 (−2.33, 2.08)0.62 (−1.40, 3.22)1.63 (−0.70, 3.78)0.003
LAVi (ml/m2)
 Baseline27.6±8.527.9±10.133.3±14.60.01
 1 yr30.5±8.732.2±9.939.1±16.1<0.001
 Change3.41 (1.32, 4.91)4.58 (1.71, 6.78)5.43 (2.32, 8.40)0.001
LV ejection fraction (%)
 Baseline69.7±6.571.4±5.869.3±7.40.06
 1 yr69.6±5.069.4±5.468.5±8.20.2
 Change0.00 (−5.07, 4.00)−1.85 (−6.46, 1.85)−0.92 (−4.95, 3.82)0.3
Midwall fraction shortening (%)
 Baseline18.0±2.417.9±1.917.6±2.50.2
 1 yr17.9±2.017.7±2.316.9±2.90.01
 Change−0.43 (−1.74, 1.71)−0.07 (−1.67, 0.84)−0.44 (−1.91, 0.69)0.4
Sm (cm/s)
 Baseline9.2±1.79.0±1.88.8±2.00.9
 1 yr8.3±1.88.4±2.08.4±2.20.7
 Change−0.92 (−2.00, 0.46)−0.80 (−1.38, 0.43)−0.46 (−1.50, 0.50)0.2
E (cm/s)
 Baseline81.7±19.177.5±19.483.2±23.30.2
 1 yr82.2±19.680.9±18.583.8±24.50.6
 Change0.00 (−0.93, 8.65)2.18 (−6.73, 12.46)0.00 (−10.15, 11.21)0.3
A (cm/s)
 Baseline77.9±18.584.3±19.493.1±23. 80.002
 1 yr79.3±19.885.2±19.894.2±27.70.01
 Change2.57 (−8.00, 13.8)−0.86 (−6.46, 5.60)2.00 (−6.87, 12.00)0.4
E/A ratio
 Baseline1.1±0.31.0±0.30.9±0.30.06
 1 yr1.1±0.51.0±0.21.0±0.70.6
 Change−0.04 (−0.22, 0.13)0.02 (−0.09, 0.18)−0.00 (−0.12, 0.08)0.2
Em (cm/s)
 Baseline10.6±2.99.9±2.59.2±2.90.04
 1 yr10.0±2.69.1±2.48.5±2.60.02
 Change−0.50 (−1.39, 0.45)−0.50 (−1.62, 0.46)−0.50 (−1.50, 0.49)1.0
Am (cm/s)
 Baseline11.0±1.611.4±2.011.9±2.60.04
 1 yr10.7±1.911.0±2.511.7±2.60.02
 Change−0.50 (−1.09, 0.50)−0.45 (−1.50, 0.92)−0.41 (−1.50, 1.38)0.9
E/Em ratio
 Baseline8.1±2.58.2±2.69.8±4.00.001
 1 yr8.6±2.79.4±3.510.6±4.80.02
 Change0.36 (−0.60, 1.57)0.91 (0.07, 2.06)0.61 (−0.50, 1.95)0.1
  • Comparisons of various echocardiographic parameters among the three groups at baseline and 1 year were done using general linear model, adjusting for age and sex. Changes over 1 year are expressed as median (IQR), and comparisons across three groups were done by Kruskal–Wallis test. Data at baseline and 1 year are expressed as mean±SD. A, peak late transmitral flow velocity; E, peak early transmitral flow velocity; E/A, ratio of early to late transmitral flow velocity.