Table 5.

Candidate gene analysis for uromodulin indexed to creatinine in the overall population

Gene NameChrSNPs Found in Gene (n)LD Blocks in Gene at R2=0.2 (n)Gene-Specific ThresholdSNPs in Gene with P Value Below Threshold (n)SNP ID with Lowest P Value in GeneLowest P Value in GeneFDReGFR Cr P Value in CKDGenGene Category
KCNJ1(ROMK)a114050.0101rs28558000.0010.19140.023Ion transport
CAB39a24360.0081rs24382980.0020.29620.065Regulator, ion transport
SORL1a1112090.0063rs15327630.0040.43810.29Regulator, ion transport
HNF1B173690.0060rs42392170.010.71780.38Transcription factor
REN12160.0080rs115710930.02>0.750.64Regulator, ion transport
STK392362150.0030rs22037030.02>0.750.19Regulator, ion transport
CLDN1421165120.0040rs48165380.03>0.750.9Paracellular, ion transport
CLDN1635660.0080rs174455300.03>0.750.69Paracellular, ion transport
CNNM21013760.0080rs127690800.06>0.750.1Ion transport
SLC9A352770.0070rs10359080.07>0.750.94Ion transport
CLCNKB12750.0100rs20074710.07>0.750.21Ion transport
SLC9A4216870.0070rs170272580.07>0.750.45Ion transport
NFAT5167560.0080rs10648250.08>0.750.017Transcription factor
SLC9A2281120.0040rs130113600.11>0.750.49Ion transport
AGT14850.0100rs37896640.11>0.750.52Regulator, ion transport
WNK11210480.0060rs71371880.13>0.750.15Regulator, ion transport
CLCNKA13430.0170rs18897850.15>0.750.34Ion transport
CASR37580.0060rs38045930.15>0.750.65Regulator, ion transport
OXSR131950.0100rs49554080.22>0.750.75Regulator, ion transport
SLC12A1154410.0500rs18431440.22>0.750.38Ion transport
CLDN191830.0170rs75480080.31>0.750.73Paracellular, ion transport
BSND12020.0250rs121341180.31>0.750.55Ion transport
WNK417110.0500rs8730840.34>0.750.2Regulator, ion transport
HIF1A142820.0250rs71431640.43>0.750.19Transcription factor
  • The table is sorted after lowest P value in the gene. Significance was defined as P value lower than a gene-specific threshold, calculated as 0.05 divided by the number of found LD blocks at R2=0.2 in that gene. Chr, chromosome; FDR, false discovery rate; Cr, creatinine.

  • a Three loci with at least one SNP with a P value below the threshold in the gene. The FDR values <0.75 are provided as an alternative threshold (see the Concise Methods).