Table 3.

Risk factors for the development of impaired GFR (sustained eGFR<60 ml/min per 1.73m2) among DCCT/EDIC study participants who developed macroalbuminuria

VariablesHazard Ratio (95% CI)P Value
Baseline variables
Age (yr)0.99 (0.95 to 1.02)0.48
Women1.19 (0.64 to 2.23)0.59
Diabetes duration (yr)1.02 (0.95 to 1.09)0.61
Smoker1.11 (0.59 to 2.10)0.74
Current use of RAAS blockers1.42 (0.68 to 2.95)0.35
Use of lipid-lowering agents1.41 (0.77 to 2.57)0.26
Body mass index (1 kg/m2)1.04 (0.97 to 1.12)0.30
SBP (per 10 mmHg)1.44 (1.20 to 1.74)<0.001
DBP (per 10 mmHg)1.62 (1.19 to 2.22)0.002
Hemoglobin A1c (%)1.50 (1.20 to 1.88)<0.001
eGFR (ml/min per 1.73 m2)0.95 (0.94 to 0.97)<0.001
AER≥1000 mg/d3.25 (1.69 to 6.25)<0.001
Time-dependent variables
 SBP (per 10 mmHg)1.70 (1.45 to 1.99)<0.001
 DBP (per 10 mmHg)2.14 (1.59 to 2.88)<0.001
 Hemoglobin A1c (per %)1.22 (1.01 to 1.48)0.04
 AER<300 versus AER≥300 mg/d0.11 (0.04 to 0.31)<0.001
  • Discrete Cox models for sustained eGFR<60 ml/min per 1.73 m2 adjusted for age, sex, and eGFR at time of incident macroalbuminuria.