Table 1.

Characteristics of participants in the DCCT/EDIC study at the time that incident macroalbuminuria was diagnosed

VariableMean (SD) or N (%)
All MacroalbuminuriaPersistent Macroalbuminuria
Number159123
Age (yr)37 (9)36 (9)
Women51 (32%)37 (30%)
Caucasian race146 (92%)114 (93%)
Duration of diabetes (yr)17 (5)17 (5)
DCCT cohort
 Primary prevention64 (40%)45 (37%)
 Secondary prevention95 (60%)78 (63%)
DCCT treatment assignment
 Intensive therapy44 (28%)35 (28%)
 Conventional therapy115 (72%)88 (72%)
Time of diagnosis of macroalbuminuria
 During DCCT52 (33%)45 (37%)
 During EDIC study107 (67%)78 (63%)
Active smoking45 (29%)39 (33%)
Current RAAS inhibitor use49 (31%)35 (29%)
Lipid-lowering medication use18 (12%)11 (9%)
Body mass index (kg/m2)26.9 (4.3)26.6 (4.0)
SBP (mmHg)133 (17)132 (17)
DBP (mmHg)82 (10)83 (10)
Hypertension (SBP>140 or DBP>90 or use of antihypertensive medications)84 (55%)63 (54%)
Hemoglobin A1c (%)9.3 (1.6)9.4 (1.6)
AER (mg/24 h)524 (383–796)549 (393–842)
eGFR (ml/min per 1.73 m2)108 (20)109 (21)
Total cholesterol (mg/dl)203 (45)206 (47)
HDL cholesterol (mg/dl)52 (15)52 (14)
Triglycerides (mg/dl)120 (77)123 (79)
LDL cholesterol (mg/dl)126 (35)128 (37)
  • Data are mean (SD) or number (%), except for albumin excretion ratio, which is median (interquartile range). SBP, systolic BP; DBP, diastolic BP.