Table 2.

Renal outcomes among 159 participants who developed incident macroalbuminuria during the DCCT/EDIC study

OutcomesNumber at RiskNumber of CasesFollow-Up (yr after Macroalbuminuria Onset)Incidence Rate (per 100 person-yr)10-yr Cumulative Incidence (%)
Sustained microalbuminuria130a614228.252
Sustained normoalbuminuria130a148221.313
Nephrotic-range albuminuria159406243.027
Sustained eGFR<60 ml/min per 1.73 m2159517244.032
eGFR<45 ml/min per 1.73 m2159468253.126
eGFR<30 ml/min per 1.73 m2159338252.122
  • Sustained microalbuminuria was defined as urine AER<300 mg/d on two successive occasions. Sustained normoalbuminuria was defined as urine AER<30 mg/d on two successive occasions. Nephrotic-range albuminuria was defined as AER≥3000 mg/d. Participants who developed ESRD were considered to have met each eGFR outcome (<60, <45, and <30 ml/min per 1.73 m2).

  • a Twenty-nine of one hundred fifty-nine participants with macroalbuminuria were not at risk for sustained microalbuminuria or normoalbuminuria, because they did not have two AER measurements after macroalbuminuria diagnosis.