Table 1.

List of genes differentially expressed in glomeruli isolated from Pod1tcf21 versus wild-type mice

Ref SeqpodTcf21 Glomeruli Microarray Analysis (Categorized)Fold Change (Mut/Con)
Gene AssignmentGene SymbolP Value
NM_011545Transcription factor 21Tcf214.02E-110.116851
Podocyte-related genes
 NM_144783Wt1 homologWt10.961.00341
 AB513652Nephrosis 1 homolog, nephrin (human)Nphs10.710.965275
 NM_019459Nephrosis 1 homolog, nephrin (human)Nphs10.820.967055
 NM_130456Nephrosis 2 homolog, podocin (human)Nphs20.690.952228
 NM_015764Gene regulated by estrogen in breast cancer proteinGreb10.041.09796
 NM_009847CD2-associated proteinCd2ap0.040.913255
 NM_001109975SynaptopodinSynpo0.010.834113
 NM_001099331R3H domain containing-likeR3hdml<0.0010.195615
Mesangial genes
 NM_010043DesminDes0.600.955636
 NM_001146268PdgfrbPdgfrb<0.0020.894954
Endothelial genes
 NM_01061Kinase insert domain protein receptorKdr0.090.953623
 NM_001111059CD34 antigenCd340.411.02267
 NM_010228FMS-like tyrosine kinase 1Flt1<0.0020.883751
 NM_013690Endothelial-specific receptor tyrosine kinaseTek0.010.890548
 NM_008816Platelet/endothelial cell adhesion molecule 1Pecam10.220.953775
VEGF-related genes
 NM_001025250VEGF-AVegfa0.010.858069
 NM_011697VEGF-BVegfb<0.0011.20935
 NM_009506VEGF-CVegfc<0.0061.46325
 NM_008827Placental growth factorPgf1.29E-050.432535
Notch pathway
 NM_008714Notch gene homolog 1 (Drosophila)Notch10.250.959897
 NM_010928Notch gene homolog 2 (Drosophila)Notch20.540.975687
 NM_019454Delta-like 4 (Drosophila)Dll4<0.0010.692084
 NM_013904Hairy/enhancer-of-split related with YRPW motif 2Hey2<0.0120.663724
 NM_013905Hairy/enhancer-of-split related with YRPW motif-likeHeyl<0.0120.8704
Heparan sulfate proteoglycans
 NM_178870Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1Hs3st3a12.83E-100.130029
 NM_016696Glypican 1Gpc14.04E-060.614059
 NM_009929Collagen, type XVIII, α1Col18a16.17E-100.473699
 NM_028072Sulfatase 2Sulf21.56E-071.84207
 NM_001198565Sulfatase 1Sulf1<0.0011.57147
 NM_016771Sulfotransferase family 1D, member 1Sult1d1<0.0012.43938
Collagens and laminins
 NM_007743Collagen, type I, α2Col1a26.51E-060.66233
 NM_007739Collagen, type VIII, α1Col8a12.42E-052.39189
 NM_007730Collagen, type XII, α1Col12a1<0.0011.42416
 NM_181277Collagen, type XIV, α1Col14a1<0.0012.93957
 NM_009929Collagen, type XVIII, α1Col18a16.17E-100.473699
 NM_008480Laminin, α1Lama1<0.0011.37389
 NM_008485Laminin, γ2Lamc20.021.3046
Wnt Signaling
 Cannonical Wnt pathway
  NM_007614Catenin (cadherin associated protein), β1Ctnnb10.040.957209
  NM_010703Lymphoid enhancer binding factor 1Lef10.010.848828
  NM_013685Transcription factor 4Tcf40.730.990435
  NM_015732Axin2Axin20.610.951149
 Wnt ligands
  NM_009523Wingless-related MMTV integration site 4Wnt40.030.894278
  ENSMUST00000045747Wingless-related MMTV integration site 4Wnt40.160.913155
  NM_009524Wingless-related MMTV integration site 5AWnt5a1.30E-050.646918
  NM_009528Wingless-related MMTV integration site 7BWnt7b0.671.03785
  NM_011720Wingless related MMTV integration site 8bWnt8b2.26E-051.45817
  NM_011719Wingless-type MMTV integration site 9BWnt9b0.391.08941
  NM_009519Wingless-related MMTV integration site 11Wnt110.050.882975
 Wnt inhibitors and related
  NM_013834Secreted frizzled-related protein 1Sfrp1>0.0011.65044
  NM_011915Wnt inhibitory factor 1Wif12.68E-113.57431
  NM_011356Frizzled-related proteinFrzb<0.0012.78872
  NM_021339Cell adhesion molecule–related/downregulated by oncogenesCdon6.57E-082.6764
 Wnt receptors
  NM_021458Frizzled homolog 3 (Drosophila)Fzd3<0.0011.29471
  NM_008055Frizzled homolog 4 (Drosophila)Fzd4>0.0071.15362
  NM_008055Frizzled homolog 7 (Drosophila)Fzd7>0.0011.34737
  NM_001008231Dishevelled associated activator of morphogenesis 2Daam2<0.0120.861158
Tgfs
 NM_031199TGF-αTgfa5.28E-050.737485
 NM_011577TGF-β1Tgfb10.781.01081
 NM_009368TGF-β3Tgfb36.43E-051.52369
 NM_009370TGF-β receptor ITgfbr10.721.01594
 NM_009371TGF-β receptor IITgfbr20.020.875323
 NM_011578TGF-β receptor IIITgfbr3<0.0030.853125
 NM_008542MAD homolog 6 (Drosophila)Smad6<0.0011.20471
 NM_001042660MAD homolog 7 (Drosophila)Smad7<0.0011.22369
Fgfs
 NM_010206Fibroblast growth factor receptor 1Fgfr14.12E-050.740399
 NM_010207Fibroblast growth factor receptor 2Fgfr2<0.0011.35853
 NM_008010Fibroblast growth factor receptor 3Fgfr3<0.0781.09647
 NM_008011Fibroblast growth factor receptor 4Fgfr48.70E-080.559123
 NM_054071Fibroblast growth factor receptor-like 1Fgfrl1>0.0041.13961
 NM_011896Sprouty homolog 1 (Drosophila)Spry15.09E-060.756577
Bmps
 NM_028472Bone morphogenetic protein–binding endothelial regulatorBmper>0.0021.24081
 NM_007554Bone morphogenetic protein 4Bmp4>0.0011.35746
 NM_007555Bone morphogenetic protein 5Bmp5<0.0071.24253
 NM_007557Bone morphogenetic protein 7Bmp70.010.867236
  • The affymetrix gene microarray platform was used to identify differences. Genes are categorized according to cell type expression or cell signaling pathways. Complete lists of genes that show at least 1.5-fold difference are shown in Supplemental Tables 2 and 3.