Table 3.

HRs and 95% CIs for ESRD per 10-pg/ml FGF-23 increment according to category of baseline kidney function in the ARIC study (1990–2010; n=13,448)

eGFR Model (ml/min per 1.73 m2)aParticipants (n)HR (95% CI)P ValueP Value for Interactionb
eGFRCr≥90
 Model 197791.09 (1.04 to 1.15)<0.001
 Model 51.11 (1.01 to 1.22)0.03
eGFRCr 60–893404
 Model 11.18 (1.07 to 1.30)0.0010.78
 Model 51.07 (0.95 to 1.21)0.250.56
eGFRCr<60265
 Model 11.10 (1.07 to 1.13)<0.0010.60
 Model 51.11 (1.01 to 1.23)0.030.21
  • a Models are as follows: model 1 is unadjusted (no covariates included in the model); and model 5 is adjusted for age, sex, race, diabetes, systolic BP, antihypertensive medication, eGFRCr, eGFRCys, eGFRCr-Cys, HDL cholesterol, body mass index, C-reactive protein, β2-microglobulin, phosphate, calcium, and parathyroid hormone.

  • b Interaction of GFR category using eGFRCr≥90 ml/min per 1.73 m2 as the reference group (all P>0.20). Dash represents reference group for test of interaction.