Table 1.

Baseline characteristics by quintile of serum level of FGF-23 in the ARIC study (1990–2010; n=13,448)

CharacteristicQuintile of Serum Level of FGF-23 (pg/ml)P Valuea
1 (<32.0)2 (32.0–38.5)3 (38.6–45.3)4 (45.4–54.6)5 (>54.6)
Participants (n)26902690268926902689
Median FGF-23 (pg/ml)27.535.641.949.563.5<0.001
Age (yr)56.3 (5.7)56.6 (5.7)56.7 (5.7)57.2 (5.7)57.6 (5.7)<0.001
Women60.056.854.153.056.4<0.001
Caucasian74.176.676.774.272.1<0.001
Body mass index (kg/m2)27.0 (5.4)27.7 (5.3)28.0 (5.2)28.3 (5.4)29.1 (5.7)<0.001
HDL (mg/dl)53.0 (17.6)50.6 (16.6)49.4 (16.5)48.0 (16.1)47.5 (16.6)<0.001
Diabetes status14.313.313.115.218.8<0.001
Systolic BP (mmHg)120.0 (18.3)120.7 (18.4)121.0 (18.3)122.0 (19.1)123.7 (19.6)<0.001
Antihypertensive medication25.928.030.534.945.6<0.001
History of coronary heart disease4.35.45.66.17.7<0.001
eGFR (ml/min per 1.73 m2)
 eGFRCr category
  <60 0.50.60.81.56.5<0.001
  60–89 18.722.024.929.331.6<0.001
  ≥9080.977.474.369.161.9<0.001
 eGFRCr100.0 (13.9)98.1 (13.7)97.3 (14.2)95.6 (15.1)91.7 (19.1)<0.001
 eGFRCys96.3 (16.2)93.8 (16.3)92.4 (16.6)89.1 (17.8)82.5 (20.8)<0.001
 eGFRCr-Cys100.5 (15.3)97.7 (14.9)96.4 (15.1)93.6 (16.3)87.9 (19.8)<0.001
C-reactive protein (mg/dl)4.41 (8.87)3.98 (5.99)4.06 (5.96)4.43 (6.86)5.07 (7.81)<0.001
Parathyroid hormone (pg/ml)40.5 (20.4)41.3 (15.6)41.7 (15.6)42.8 (16.6)45.1 (24.1)<0.001
Phosphate (mg/dl)3.47 (0.47)3.51 (0.47)3.51 (0.47)3.56 (0.47)3.63 (0.52)<0.001
Calcium (mg/dl)9.28 (0.41)9.31 (0.44)9.33 (0.40)9.39 (0.42)9.45 (0.46)<0.001
β2-Microglobulin (mg/L)1.80 (0.41)1.84 (0.43)1.88 (0.40)1.95 (0.47)2.19 (1.07)<0.001
  • Data are presented as the mean (SD) or percentage unless otherwise specified.

  • a ANOVA for continuous variables and chi-squared test for categorical variables.