Table 2.

Baseline demographic, clinical, and biochemical characteristics of CRIC Study participants without HF at baseline by quintile of NT-proBNP

CharacterisiticsNT-proBNP Quintile (n), pg/mlaP Value
≤47.6 (n=697)>47.6–95.8 (n=697)>95.8–188.8 (n=696)>188.8–433.0 (n=697)>433.0 (n=696)
Age, yr52.9 (11.7)57.2 (10.8)58.9 (11.2)59.9 (10.5)60.5 (10.0)<0.001
Women232 (33.3%)330 (47.3%)338 (48.6%)370 (53.1%)317 (45.5%)<0.001
Race/ethnicity<0.001
 Non-Hispanic white300 (43.0%)306 (43.9%)325 (46.7%)309 (44.3%)252 (36.2%)
 Non-Hispanic black317 (45.5%)295 (42.3%)264 (37.9%)254 (36.4%)263 (37.8%)
 Hispanic45 (6.5%)62 (8.9%)88 (12.6%)103 (14.8%)157 (22.6%)
 Other35 (5.0%)34 (4.9%)19 (2.7%)31 (4.4%)24 (3.4%)
eGFR, ml/min per 1.73 m2b58.1 (16.8)49.7 (16.4)45.2 (15.3)40.6 (13.8)35.0 (12.4)<0.001
24-hour urine protein, g/d0.1 (0.06–0.3)0.1 (0.07–0.6)0.2 (0.07–0.7)0.2 (0.08–1.1)0.7 (0.1–2.8)<0.001
Diabetes218 (31.3%)291 (41.8%)315 (45.3%)362 (51.9%)429 (61.6%)<0.001
History of MI/stroke/PAD79 (11.3%)121 (17.4%)172 (24.7%)215 (30.8%)323 (46.4%)<0.001
Current smoker66 (9.5%)76 (10.9%)83 (11.9%)99 (14.2%)124 (17.8%)<0.001
Alcohol use511 (73.3%)496 (71.2%)433 (62.2%)419 (60.1%)371 (53.3%)<0.001
Body mass index, kg/m231.8 (6.6)32.0 (7.5)32.1 (8.4)32.0 (8.3)31.6 (7.7)0.76
Systolic BP, mmHg118.9 (15.2)124.0 (18.5)125.0 (18.7)131.8 (22.0)142.5 (26.1)<0.001
Diastolic BP, mmHg73.0 (11.1)72.4 (11.4)70.1 (11.8)71.3 (13.2)72.7 (14.9)<0.001
Hemoglobin, g/dl13.6 (1.6)12.9 (1.5)12.6 (1.6)12.3 (1.7)11.8 (1.9)<0.001
LDL cholesterol, mg/dl107.7 (34.0)104.5 (35.0)104.0 (35.5)101.8 (34.1)101.2 (37.8)0.005
HDL cholesterol, mg/dl47.1 (14.2)48.2 (15.3)49.0 (15.8)48.8 (16.8)46.7 (15.7)0.02
ACE/ARB use457 (66.2%)467 (67.6%)479 (69.1%)481 (69.5%)458 (66.3%)0.56
Diuretic use292 (42.3%)369 (53.4%)404 (58.3%)401 (57.9%)482 (69.8%)<0.001
β-Blocker use157 (22.8%)242 (35.0%)305 (44.0%)405 (58.5%)482 (69.8%)<0.001
FGF23, RU/ml99.6 (73.4–144.8)122.7 (86.2–183.7)133.2 (94.6–206.0)159.3 (107.4–244.5)209.1 (136.2–344.0)<0.001
Serum phosphorus, mg/dl3.5 (0.6)3.6 (0.6)3.7 (0.7)3.8 (0.7)3.9 (0.7)<0.001
Total PTH, pg/ml41.0 (29.4–56.0)47.8 (32.6–77.3)51.5 (32.0–78.6)57.0 (37.0–94.0)74.0 (46.0–123.4)<0.001
EF from echocardiogramc55.6 (6.4)56.1 (6.1)55.6 (7.0)54.8 (7.7)52.2 (9.5)<0.001
LVMI, g/m2.7c45.3 (10.4)48.6 (11.4)49.9 (12.3)52.4 (13.2)59.7 (15.4)<0.001
  • MI, myocardial infarction; PAD, peripheral arterial disease; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; RU, relative units.

  • a NT-proBNP categories were defined by quintiles.

  • b eGFR calculated using serum creatinine and cystatin C (47).

  • c From the year 1 clinic visit.