Table 1.

Comparison of the KDIGO and ACC/AHA guidelines: Criteria for statin prescription in people with nondialysis-dependent CKD (any stage)

Aged ≥50 yrAged <50 yr
KDIGOACC/AHAKDIGOACC/AHA
AllKnown vascular diseaseaKnown vascular diseaseaKnown vascular diseasea
LDL-C>190 mg/dlLDL-C>190 mg/dl
Diabetes+age 40–79 yr+LDL-C 70–189 mg/dlDiabetesDiabetes+age 40–79 yr+LDL-C 70–189 mg/dl
10-yr predicted risk for vascular eventb >7.5% using the pooled cohort risk equations10-yr predicted risk for vascular eventb >10%10-yr predicted risk for vascular eventb >7.5% using the pooled cohort risk equations
  • Nondialysis-dependent CKD is defined by eGFR<60 ml/min per 1.73 m2 or albuminuria>30 mg/g.

  • a Known vascular disease was defined by KDIGO as myocardial infarction, stroke, or coronary revascularization and was defined by ACC/AHA as myocardial infarction, stroke, coronary revascularization, peripheral revascularization, or aortic aneurysm repair.

  • b Future vascular events were defined by KDIGO as cardiovascular death or nonfatal myocardial infarction and were defined by ACC/AHA as fatal/nonfatal stroke, myocardial infarction, and death from coronary disease.