Table 1.

Patients’ characteristics in NephroTest study according to ACR

CharacteristicACR<3 mg/mmolACR 3–30 mg/mmolACR≥30 mg/mmolP Value
Patients (n)574575589
Age (yr)62.07±14.0359.69±15.0457.06±15.59<0.001
Men 64.6 (371)68.7 (395)67.9 (400)0.2
Body mass index (kg/m2)26.20±5.1026.62±5.0127.15±5.550.002
Sytolic BP (mmHg)131.44±17.84134.49±19.89142.24±21.39<0.0.001
Diastolic BP (mmHg)72.00±10.8774.43±11.3578.02±12.4<0.001
Diabetes, n (%)19.9 (114)28.4 (162)32.3 (190)<0.001
Cardiovascular disease16.5 (92)20.4 (116)19.7 (114)0.2
mGFR (ml/min per 1.73 m2)47.62 (36.38–61.38)37.4 (26.81–52.11)28.71 (18.86–41.76)<0.001
Albuminemia (g/L)40.35±3.6739.90±3.9636.93±4.84<0.001
Ca2+ (mmol/L)1.22±0.061.22±0.071.21±0.07<0.001
25(OH)2D (ng/ml)20 (13–29)20 (12.8–30)16.4 (10–24)<0.001
1,25(OH)2D3 (pg/ml)31.25 (22.08–43.17)27.00 (18–37.5)22.92 (15.21–32)<0.001
iPTH (pg/ml)47 (32–71)62 (39–97)88 (47–151)<0.001
Hemoglobin (g/dl)12.99±1.4912.67±1.6712.22±1.7<0.001
Ferritin (µg/L)115 (61–213)119.5 (65–216)116 (61–196)0.2
Phosphate (mmol/L)1.03±0.171.07±0.211.17±0.26<0.001
Protein intake (g/kg per 24 hr)1.05±0.291.03±0.290.97±0.29<0.001
FGF-23 (pg/ml) (n=397)54.2 (41.9–75.6)59.4 (42.6–111)86.4 (55.9–181)<0.001
Type of nephropathy <0.001
 Diabetic5.1 (29)8.0 (46)17.5 (103)
 Vascular32.4 (186)30.6 (176)21.1 (124)
 Primary GN6.1 (35)12.5 (72)23.3 (137)
 Polycystic kidney disease6.1 (35)10.3 (59)1.7 (10)
 Interstitial9.2 (53)9.2 (53)7.0 (41)
 Other41.1 (236)29.4 (169)29.5 (174)
Treatment
 Vitamin D10.8 (58)17.9 (98)15.7 (90)0.03
 Active vitamin D7.5 (40)10.0 (55)11.5 (66)0.02
 Phosphate binders0.6 (3)1.3 (7)4.2 (24)<0.001
  • Unless otherwise noted, values are expressed as the mean±SD, median (interquartile range), or % (n). iPTH, intact parathyroid hormone.