Table 2.

Unadjusted HRs for the development of death or dialysis within 9 months from univariate Cox proportional hazards models

VariableUnadjusted HR (95% CI)P Value
AKIa2.07 (1.55 to 2.77)<0.001
History of CKD1.69 (1.13 to 2.51)0.01
Reason for ICU admission
 Respiratory2.18 (1.66 to 2.86)<0.001
 Surgery0.44 (0.31 to 0.61)<0.001
 Trauma0.61 (0.32 to 1.30)0.24
Serum creatinineb1.29 (1.05 to 1.15)0.02
[TIMP-2]⋅[IGFBP7]>0.3 to ≤2.0c1.22 (0.91 to 1.62)0.18
[TIMP-2]⋅[IGFBP7]>2.0c2.11 (1.37 to 3.23)<0.001
  • Overall P value for univariate [TIMP-2]⋅[IGFBP7] is 0.04 (likelihood ratio test). HRs are not provided for age and nonrenal APACHE III, because they did not satisfy the proportional hazards assumptions.

  • a KDIGO stage 1 or higher AKI within 72 hours after urine [TIMP-2]⋅[IGFBP7] sample collection.

  • b Log2 transformed; the serum sample was collected at the same time as the urine sample for [TIMP-2]⋅[IGFBP7] testing.

  • c Relative to [TIMP-2]⋅[IGFBP7]≤0.3.