Table 3.

Adjusted HRs for death or dialysis within 9 months from a multivariate Cox proportional hazards model

VariableaAdjusted HRb (95% CI)P Value
History of CKD1.41 (0.92 to 2.17)0.11
Reason for ICU admission
 Respiratory1.74 (1.27 to 2.38)0.001
 Surgery0.51 (0.35 to 0.74)<0.001
 Trauma0.97 (0.50 to 1.88)0.93
No AKIc
 Serum creatinined0.80 (0.56 to 1.13)0.20
 [TIMP-2]⋅[IGFBP7]>0.3 to ≤2.0e0.71 (0.43 to 1.18)0.19
 [TIMP-2]⋅[IGFBP7]>2.0e0.63 (0.15 to 2.64)0.53
AKIc
 Serum creatinined1.40 (1.08 to 1.81)0.01
 [TIMP-2]⋅[IGFBP7]>0.3 to ≤2.0e1.44 (1.00 to 2.06)0.05
 [TIMP-2]⋅[IGFBP7]>2.0e2.16 (1.32 to 3.53)0.002
  • C statistic=0.70 (0.67–0.74; P<0.001) under the null hypothesis of AUC=0.5 for the multivariate model.

  • a Age and APACHE III were included in the model as stratification terms to stratify the baseline hazard function and were not regression terms, because these variables violated the proportional hazards assumption; therefore, no HRs are reported for these variables.

  • b Covariate-adjusted HR for each variable.

  • c AKI is defined as KDIGO stage 1 or higher within 72 hours after urine [TIMP-2]⋅[IGFBP7] sample collection.

  • d Log2-transformed serum creatinine from a sample collected at the same time as the urine sample for [TIMP-2]⋅[IGFBP7] testing. We elected to use log2-transformed serum creatinine, because a 10-fold change in serum creatinine is not a clinically meaningful scale.

  • e Relative to [TIMP-2]⋅[IGFBP7]≤0.3.