Table 2.

Contributions of genetic ancestry, APOL1, and self-reported ancestry to normal renal function and disease states in full model*

CharacteristicsGenetic African Ancestry (per 10%)APOL1 Risk HaplotypeComparison of AA Versus (P Value)
β or OR (95% CI)P Valueβ or OR (95% CI)P ValueEAH/LA
AAs
 Log creatininea0.02 (0.008 to 0.03)1×10−40.08 (0.04 to 0.12)1×10−4
 Log creatininea restrictedb0.01 (0.007 to 0.016)3×10−70.0003 (−0.02 to 0.02)0.98
 eGFR (ml/min per 1.73 m2)−1.62 (−2.19 to −1.04)3×10−8−2.69 (−5.12 to −0.25)0.03
 eGFR>90 ml/min per 1.73 m2−1.07 (−1.52 to −0.62)4×10−6−0.94 (−3.04 to 1.15)0.36
 Elevated creatininec1.14 (1.06 to 1.23)0.0011.27 (0.98 to 1.66)0.07
 CKD1.19 (1.09 to 1.30)1×10−41.32 (0.98 to 1.79)0.07
 eGFR<45 ml/min per 1.73 m21.07 (0.96 to 1.20)0.221.69 (1.15 to 2.48)0.007
 ESRD (eGFR<15 ml/min per 1.73 m2)1.09 (0.93 to 1.28)0.312.69 (1.66 to 4.35)5×10−5
H/LAs
 Log creatininea0.009 (0.003 to 0.01)0.0010.26 (0.18 to 0.35)2×10−9
 Log creatininea restrictedb0.009 (0.005 to 0.01)7×10−80.01 (−0.05 to 0.06)0.82
 eGFR (ml/min per 1.73 m2)−0.87 (−1.18 to −0.56)4×10−8−11.33 (−16.14 to −6.51)4×10−6
 eGFR>90 ml/min per 1.73 m2−0.34 (−0.60 to −0.09)0.008−2.32 (−6.49 to 1.85)0.27
 Elevated creatininec1.09 (1.03 to 1.14)0.0013.46 (1.86 to 6.43)9×10−5
 CKD1.03 (0.98 to 1.09)0.203.02 (1.57 to 5.81)0.001
 eGFR<45 ml/min per 1.73 m21.05 (0.99 to 1.12)0.134.07 (1.92 to 8.65)2×10−4
 ESRD (eGFR<15 ml/min per 1.73 m2)0.89 (0.79 to 1.01)0.0711.06 (4.47 to 27.35)2×10−7
All individuals
 Log creatininea0.01 (0.008 to 0.02)2×10−80.11 (0.07 to 0.14)2×10−50.590.12
 Log creatininea restrictedb0.01 (0.007 to 0.01)1×10−140.002 (−0.17 to 0.02)0.830.020.19
 eGFR (ml/min per 1.73 m2)−1.17 (−1.44 to −0.90)4×10−17−4.23 (−6.20 to −2.26)2×10−5<0.001<0.001
 eGFR>90 ml/min per 1.73 m2−0.64 (−0.87 to −0.40)4×10−8−1.27 (−2.89 to 0.35)0.13<0.001<0.001
 Elevated creatininec1.11 (1.07 to 1.16)9×10−81.49 (1.17 to 1.91)0.0010.240.49
 CKD1.08 (1.04 to 1.13)1×10−41.57 (1.19 to 2.05)0.0010.120.02
 eGFR<45 ml/min per 1.73 m21.08 (1.02 to 1.14)0.0082.01 (1.43 to 2.83)7×10−50.020.13
 ESRD (eGFR<15 ml/min per 1.73 m2)0.99 (0.90 to 1.08)0.773.54 (2.30 to 5.41)8×10−50.090.16
  • *Adjusted for age, sex, diabetes status, SBP, DBP, BMI, and smoking.

  • a Natural log of creatinine used in model.

  • b Creatinine<1.3 mg/dl in men and <1.1 mg/dl in women.

  • c Creatinine≥1.3 mg/dl in men and ≥1.1 mg/dl in women.