Table 4.

Significant changes between CAN and SI versus TOL for 21 genes in 417 peripheral blood samples across 5 independent platforms.

TOL versus CAN	Gene ID	q Value (%)			P Values
TOL versus CAN	Gene ID	Agilent	Lymphochip	Affymetrix	SAB	Fluidigm
BNC2	54796	0.0000	Not expressed	0.0000	0.0002	0.0000
CYP1B1	1545	0.0000	Not expressed	0.0000	0.0001	0.0000
KLF6	1316	1.4100	3.5000	3.2468	0.0000	0.0096
IGFL2	147920	4.9800	Not expressed	0.0000	0.0059	0.0000
CCL4	6351	0.0000	Not expressed	0.0000	0.0000	0.04
SHCBP1	79801	0.0000	Not expressed	NS	0.0001	0.03
SPC25	57405	0.0000	0.8500	NS	0.014	0.07
UHRF1	29128	1.4100	0.0000	NS	0.0099	0.0024
NXF3	56000	3.7000	Not expressed	5.9524	0.0000	Not expressed
IGHA2	3494	0.0000	Not expressed	Not expressed	0.02	0.47
TNFRSF17	608	0.0000	0.0000	0.0000	0.0009	0.22
IGJ	3512	0.0000	0.8500	0.0000	0.17	0.71
IGHG1^a	3500	0.0000	Not expressed	NS	0.068	0.27
IGHG4^a	3503	0.0000	Not expressed	NS	0.068	0.27
IGH@	3492	0.0000	Not expressed	0.7666	0.47	Not expressed
FAM110C	642273	0.0000	Not expressed	0.0000	0.0000	0.67
VN1R2	317701	1.4100	Not expressed	NS	0.02	0.36
CLVS1	157807	1.4100	Not expressed	NS	0.05	Not expressed
GDEP	118425	3.7000	Not expressed	NS	0.0005	Not expressed
C1QC	714	3.7000	Not expressed	NS	0.0000	0.64
PRAMEF3	401940	4.9800	Not expressed	NS	0.02	Not expressed
TFDP3	51270	3.7000	Not expressed	NS	0.30	0.66

Significance of the 21 genes between TOL and CAN were calculated by SAM¹³ for microarray data (Agilent, Lymphochip, Affymetrix) and between TOL and SI by two-sided t test for qPCR data (SAB, Fluidigm). Any q value ≤5% and P value ≤0.05 were considered to represent a statistically significant difference. NS, nonsignificant by q≤5%.
↵a IGHG1/IGHG4 represented by same qPCR primer/probe set.