Table 4.

Significant changes between CAN and SI versus TOL for 21 genes in 417 peripheral blood samples across 5 independent platforms.

TOL versus CANGene IDq Value (%)P Values
AgilentLymphochipAffymetrixSABFluidigm
BNC2547960.0000Not expressed0.00000.00020.0000
CYP1B115450.0000Not expressed0.00000.00010.0000
KLF613161.41003.50003.24680.00000.0096
IGFL21479204.9800Not expressed0.00000.00590.0000
CCL463510.0000Not expressed0.00000.00000.04
SHCBP1798010.0000Not expressedNS0.00010.03
SPC25574050.00000.8500NS0.0140.07
UHRF1291281.41000.0000NS0.00990.0024
NXF3560003.7000Not expressed5.95240.0000Not expressed
IGHA234940.0000Not expressedNot expressed0.020.47
TNFRSF176080.00000.00000.00000.00090.22
IGJ35120.00000.85000.00000.170.71
IGHG1a35000.0000Not expressedNS0.0680.27
IGHG4a35030.0000Not expressedNS0.0680.27
IGH@34920.0000Not expressed0.76660.47Not expressed
FAM110C6422730.0000Not expressed0.00000.00000.67
VN1R23177011.4100Not expressedNS0.020.36
CLVS11578071.4100Not expressedNS0.05Not expressed
GDEP1184253.7000Not expressedNS0.0005Not expressed
C1QC7143.7000Not expressedNS0.00000.64
PRAMEF34019404.9800Not expressedNS0.02Not expressed
TFDP3512703.7000Not expressedNS0.300.66
  • Significance of the 21 genes between TOL and CAN were calculated by SAM13 for microarray data (Agilent, Lymphochip, Affymetrix) and between TOL and SI by two-sided t test for qPCR data (SAB, Fluidigm). Any q value ≤5% and P value ≤0.05 were considered to represent a statistically significant difference. NS, nonsignificant by q≤5%.

  • a IGHG1/IGHG4 represented by same qPCR primer/probe set.