Table 2.

Relationship between time period of initiation, clinical presentation, and eGFR at initiation

PopulationeGFR=10–15 ml/min per 1.73 m2, %eGFR>15 ml/min per 1.73 m2, %Adjusted Odds Ratio for 2005–2009 Versus 2000–2004 (95% Confidence Interval)a
eGFR=10–15 ml/min per 1.73 m2eGFR>15 ml/min per 1.73 m2 per yr
All patients (n=1691)b
 2000–200423.412.1
 2005–200929.916.31.43 (1.13 to 1.81)1.46 (1.09 to 1.97)
Acutely ill (n=841)
 2000–200419.714.8
 2005–200929.315.61.65 (1.16 to 2.34)1.12 (0.74 to 1.71)
Not acutely ill (n=850)
 2000–200427.09.4
 2005–200930.617.01.28 (0.92 to 1.76)2.02 (1.29 to 3.18)
Gastrointestinal signs and/or symptoms (n=860)
 2000–200426.78.1
 2005–200925.215.60.97 (0.69 to 1.35)2.06 (1.29 to 3.28)
Cardiopulmonary signs and/or symptoms (n=823)
 2000–200422.915.2
 2005–200933.417.81.67 (1.19 to 2.34)1.28 (0.85 to 1.93)
Fatigue and/or weakness (n=640)
 2000–200426.87.3
 2005–200929.119.81.32 (0.90 to 1.92)3.28 (1.91 to 5.64)
Electrolyte abnormalities (n=307)
 2000–200416.611.3
 2005–200926.912.21.70 (0.89 to 3.24)1.15 (0.53 to 2.50)
Neurologic signs and/or symptoms (n=281)
 2000–200420.014.1
 2005–200928.116.41.52 (0.80 to 2.88)1.04 (0.48 to 2.22)
Other signs and/or symptoms (n=357)
 2000–200417.710.3
 2005–200931.914.82.31 (1.30 to 4.13)1.64 (0.78 to 3.44)
  • a Referent eGFR<10 ml/min per 1.73 m2. Adjusted for age, race, sex, diagnoses of diabetes, congestive heart failure, ischemic heart disease, peripheral arterial disease, stroke, chronic obstructive pulmonary disease, risk score, eGFR slope during the year before initiation, site of initiation (inpatient versus outpatient), type of access at initiation (peritoneal dialysis catheter, hemodialysis graft or fistula, or hemodialysis catheter), and number of VA nephrology outpatient visits during the year before initiation.

  • b Adjusted analyses among all patients are additionally adjusted for whether the patient was acutely ill and signs and/or symptoms documented at the time of initiation.